Study of TUB-030 for Advanced Solid Tumors

This study is testing a new drug called TUB-030 for adults with advanced solid tumors, including head and neck cancer (HNSCC), small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC), and triple-negative breast cancer (TNBC). The main goals are to find out how safe TUB-030 is, what side effects it might cause, and the highest dose that can be given safely (maximum tolerated dose or MTD). Researchers will also see if TUB-030 works to treat these cancers. You might be able to join if you are 18 or older, have good organ function, and have waited a certain time after your last cancer treatment. This trial is looking to enroll about 250 participants.

Study design
This is an interventional study, meaning participants will receive the drug TUB-030. It aims to enroll 250 participants.
What's involved
You would receive TUB-030 intravenously (through a vein) every 3 weeks. You will also visit the clinic every 3 weeks for checkups and tests, and answer questionnaires about your symptoms.
Compensation
Not stated in the trial record.
Follow-up
Your safety will be monitored from enrollment until 30 days after your last dose of TUB-030.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06657222

First in Human Study of TUB-030 in Patients With Advanced Solid Tumors

Recruiting
PHASE1Ages 18+InterventionalTreatment
Tubulis GmbH
~250 participants
Updated 2026-08-14 on ClinicalTrials.gov
What's tested:TUB-030

At a glance

Recruiting sites
18 of 18 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Determination of MTD
Measured over From enrollment until 30 days after last study drug
Advanced Solid Tumors
HNSCC
SCLC
NSCLC
TNBC - Triple-Negative Breast Cancer
CRC
18 sites across 12 states
Texas3
Massachusetts2
Ohio2
Romania2
Spain2
Connecticut1
Florida1
Minnesota1
  • Yariv Houvras, MD, PhD · STUDY_DIRECTOR · Tubulis GmbH

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  • Determination of MTDFrom enrollment until 30 days after last study drug

    The highest dose is defined at which no more than 1 of 3 patients have had a Dose Limiting Toxicity (DLT) according to NCI CTCAE V5.0 criteria