Observational Study on EGFR Gene in Lung Cancer

This study is looking into the EGFR gene, which is often changed in non-small cell lung cancer. Researchers have a new way to estimate the risk of getting a cancer-related gene change. They will collect blood samples from people with EGFR-positive lung cancer and healthy individuals. They will then look at the DNA sequence around the EGFR gene using a method called gene sequencing. The goal is to use these samples to check if their risk assessment model works, which could eventually help understand who might be more likely to get EGFR-positive lung cancer or other cancers. This study is open to women between 18 and 100 years old.

Study design
This is an observational study aiming to enroll 20 participants. It compares DNA sequences from individuals with EGFR-positive lung cancer to healthy individuals.
What's involved
You would have a 10ml blood sample taken for gene sequencing. The primary endpoint, which is looking at differences in DNA sequences, will be measured from enrollment to the end of data analysis at 6 months.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured from enrollment to the end of data analysis at 6 months.

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NCT06659458

Utilizing Long-read Sequencing to Investigate the EGFR Landscape of EGFR Positive Lung Cancer Patients

Recruiting
Not specifiedAges 18+Observational
Our Lady of the Lake Hospital
~20 participants
Updated 2025-03-20 on ClinicalTrials.gov
What's tested:blood drawGene sequencing

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Differences in DNA sequence of EGFR gene
Measured over From enrollment to end of data analysis at 6 months
Lung Cancer - Non Small Cell
EGFR Exon 19 Deletion Mutation
1 sites across 1 states
Louisiana1

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Eligibility criteria

Inclusion

18-100 years old
Biologically born female
Diagnosed with EGFR positive lung cancer (Arm 1-Cancer group)
No cancer diagnosis (Arm 2-health control)

Exclusion

less than 18 years of age
Biologically born male
Incarcerated at the time of participation
  • Differences in DNA sequence of EGFR geneFrom enrollment to end of data analysis at 6 months

    Subjects who have EGFR positive lung cancer will have their gene sequence compared to those that are EGFR negative and do not have lung cancer to look for differences in the sequence.