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Study on Pain and Alcohol Use in Temporomandibular Disorder (TMD)

This study is looking at how pain affects drinking habits in people who drink heavily, both with and without chronic temporomandibular disorder (TMD) pain. TMD is a condition that causes pain in the jaw joint and surrounding muscles. Participants will receive either ethanol (alcohol) or sparkling water. Researchers will measure how much alcohol is consumed and how intense heat pain is after 30 minutes. You may be able to join if you are between 21 and 65 years old, can speak English fluently, and provide a valid ID. The study aims to understand if pain influences alcohol use. The current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 160 participants. It compares the effects of alcohol to a control condition (sparkling water).
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary measurements for this study are taken at 30 minutes after the intervention.

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NCT06659991

JIT: Effect of Pain on DT in TMD

Recruiting
EARLY_PHASE1Ages 21–65InterventionalBasic science
University of Minnesota
~160 participants
Updated 2026-07-09 on ClinicalTrials.gov
What's tested:alcohol conditioncontrol condition

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Alcohol Use Topography
Measured over 30 minutes
+1 more outcome measured

Conditions

Temporomandibular Disorder (TMD)

Explore related trials

Chronic PainTemporomandibular Joint Disorder

Where it's being run

1 sites across 1 states
Minnesota1

Study leadership

  • Jeff Boissoneault · PRINCIPAL_INVESTIGATOR · University of Minnesota

Who to contact

Jeff Boissoneault
[email protected]
612-624-6357
Email the study team

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Eligibility criteria

Inclusion

Participants in this study must be 21 years to 65 years of age and provide a driver's license or other state-issued ID.
Participants must also be sufficiently fluent in English to provide informed consent and understand questionnaires and instructions for laboratory procedures.
Participants must report drinking of, on average, at least 1 drink 3 days/week over the past 6 months.
Meet Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for myalgia (masticatory muscle pain), arthralgia (TMJ pain), or a combination (Schiffman et al., 2014) (TMD group only).
Own a smartphone with internet access.
Use of prescription medications will be allowed, provided they do not contraindicate alcohol use.

Exclusion

Use of opioid analgesics within the past month;
Current major depression;
History of any psychotic disorder;
Under-controlled hypertension or diabetes (as reflected by self-report); neurological disease (e.g., multiple sclerosis, epilepsy, amyotrophic lateral sclerosis, Parkinson's disease);
Serious medical illness (e.g., hepatitis, HIV/AIDS);
Impaired cognitive function;
History of substance use disorder (including nicotine/tobacco);
Alcohol naïve
Alcohol use disorder, or currently attempting to quit or cut down on using alcohol
Positive pregnancy test
Breastfeeding or intending to become pregnant
Loss of sensation in the lower leg
Inability to complete study tasks due to weakness, immobilization, or loss of limbs
Chronic pain (Control group only)
A urine-based drug screen for tetrahydrocannabinol, cocaine, benzodiazepines, morphine, and methamphetamine (Innovacon, Inc., San Diego, CA) will be performed. Participants testing positive for any substance will be discontinued.
Medications that contraindicate alcohol use

What this trial measures

  • Alcohol Use Topography30 minutes

    Variables reflecting microstructure of alcohol use during self-administration, including sip interval and sip volume.

  • Heat Pain Intensity30 minutes

    Pain intensity of heat stimuli applied during self- administration sessions.