Remote Hearing Tests for Head and Neck Cancer Patients

This study is looking at different ways to monitor hearing in people with head and neck squamous cell carcinoma (HNSCC) who are receiving cisplatin chemotherapy and/or radiation. These treatments can sometimes cause hearing loss. The study wants to see if offering hearing tests (audiometry) closer to your home or that you can do yourself remotely, helps more people get their hearing checked. The main goal is to see how many patients complete at least one hearing test up to 12 months after their treatment. You might be able to join if you are an adult (18 or older) with pathologically proven HNSCC. The study aims to enroll 118 participants.

Study design
This interventional study plans to enroll 118 participants. It compares standard in-person hearing tests with options for closer-to-home or self-administered remote hearing tests.
What's involved
You would undergo hearing tests at the start of the study and again at 3 and 12 months after your chemotherapy and/or radiation treatment. Some participants may also complete an interview.
Compensation
Not stated in the trial record.
Follow-up
Your participation in hearing monitoring will be tracked for up to 12 months after your treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06662058

Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation

Recruiting
NAAges 18+InterventionalScreening
Emory University
~118 participants
Updated 2026-07-16 on ClinicalTrials.gov
What's tested:Audiometric TestInterview

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Proportion of patients who complete at least one post-treatment audiogram
Measured over Up to 12 months post-treatment
Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
Cutaneous Squamous Cell Carcinoma of the Head and Neck
Head and Neck Carcinoma of Unknown Primary
Head and Neck Squamous Cell Carcinoma
Hypopharyngeal Squamous Cell Carcinoma
Laryngeal Squamous Cell Carcinoma
Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck
Metastatic Head and Neck Squamous Cell Carcinoma
Metastatic Hypopharyngeal Squamous Cell Carcinoma
Metastatic Laryngeal Squamous Cell Carcinoma
Metastatic Nasopharyngeal Squamous Cell Carcinoma
Metastatic Oral Cavity Squamous Cell Carcinoma
Metastatic Oropharyngeal Squamous Cell Carcinoma
Metastatic Paranasal Sinus Squamous Cell Carcinoma
Nasopharyngeal Squamous Cell Carcinoma
Oral Cavity Squamous Cell Carcinoma
Oropharyngeal Squamous Cell Carcinoma
Paranasal Sinus Squamous Cell Carcinoma
Recurrent Cutaneous Squamous Cell Carcinoma of the Head and Neck
Recurrent Head and Neck Squamous Cell Carcinoma
Recurrent Hypopharyngeal Squamous Cell Carcinoma
Recurrent Laryngeal Squamous Cell Carcinoma
Recurrent Nasopharyngeal Squamous Cell Carcinoma
Recurrent Oral Cavity Squamous Cell Carcinoma
Recurrent Oropharyngeal Squamous Cell Carcinoma
Recurrent Paranasal Sinus Squamous Cell Carcinoma
Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8
Stage IV Hypopharyngeal Carcinoma AJCC v8
Stage IV Laryngeal Cancer AJCC v8
Stage IV Lip and Oral Cavity Cancer AJCC v8
Stage IV Nasopharyngeal Carcinoma AJCC v8
Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Stage IV Sinonasal Cancer AJCC v8
1 sites across 1 states
Georgia1
  • Nicole C Schmitt, MD, FACS · PRINCIPAL_INVESTIGATOR · Emory University Hospital/Winship Cancer Institute

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Adult patients, male or female, aged ≥ 18, able to provide informed consent
Subjects with pathologically proven HNSCC involving the oral cavity, oropharynx, larynx, hypopharynx, nasopharynx, skin, or paranasal sinuses; patients with unknown primary HNSCC involving the cervical lymph nodes can also be included. Patients can have previously untreated or recurrent/metastatic disease
Subjects who will be treated with cisplatin chemotherapy and/or radiation. For radiation alone, patients should have tumors near the inner ear, including the nasopharynx, temporal bone, and/or parotid salivary gland
Life expectancy of more than 3 months, as determined by the investigator

Exclusion

Patients with profound hearing loss in both ears, which precludes an accurate hearing test. This can be determined based on patient report/history or audiogram done before or after informed consent
Patients who are unable to participate in a hearing test (per the investigator's judgment)
  • Proportion of patients who complete at least one post-treatment audiogramUp to 12 months post-treatment

    The incidence of follow-up audiometry relative to the targeted intervention will be assessed using a Z test for the equality of two proportions. An ordinal logistic regression analysis with mixed effects and calculations of odds ratios and 95% confidence intervals will be applied to identify associations between follow-up audiometry and intervention after adjustment for covariates including age, sex, race/ethnicity, pre-existing hearing loss, comorbidities, smoking, cisplatin dose (individual and cumulative) and cochlear radiation dose will be performed to assess whether the targeted intervention for at-risk patients is an independent predictor of increased overall participation.