Greater Houston Area Pediatric Bipolar Registry

This study is creating a registry of children and adolescents in the Greater Houston Area who have been diagnosed with Bipolar Disorder (BD), children whose parents have BD, and healthy children. The goal is to understand more about BD in young people. Researchers will collect blood and saliva samples to look for biomarkers (biological signs) and genetic information related to BD. They will also use MRI (Magnetic Resonance Imaging) scans to study brain structures. You may be eligible if you are between 6 and 17 years old and have a diagnosis of Bipolar Disorder, or if one of your parents has Bipolar Disorder. The study aims to identify BD using a specific interview tool (MINI Kid 7.2) and will follow participants annually until they are 25 years old. This is an observational study, meaning researchers will gather information without providing any specific treatments.

Study design: This is an observational study aiming to enroll 1000 participants. It involves children and adolescents with Bipolar Disorder, offspring of parents with Bipolar Disorder, and healthy controls.
What's involved: Participants will undergo a comprehensive research assessment, including blood and saliva sample collection, and MRI scans. They will be followed annually until they turn 25 years old.
Compensation: Not stated in the trial record.
Follow-up: Participants will be followed annually until they turn 25 years of age.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Greater Houston Area Pediatric Bipolar Registry

Recruiting

Not specifiedAges 6–17Observational

The University of Texas Health Science Center, Houston

~1,000 participants

Updated 2026-02-18 on ClinicalTrials.gov

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Positive Identification of Bipolar Disorder as Assessed by Mini-International Neuropsychiatric Interview for Children and Adolescents (MINI Kid 7.2) (child)

Measured over baseline, annually until participant turns 25 years of age

Conditions

Pediatric Bipolar Disorder

Where it's being run

1 sites across 1 states

Texas1

Study leadership

Jair C Soares, M.D. PhD · PRINCIPAL_INVESTIGATOR · The University of Texas Health Science Center, Houston

Who to contact

Jair C Soares, M.D. PhD

[email protected]

(713) 486-6663

Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Any current mood state (in the case of bipolar subjects)

For bipolar patients: DSM-V criteria for BD type I, BD type II, or BD NOS, as per the administration of the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)

For the offspring of bipolar parents: at least one parent meeting DSM-V criteria for BD type I or BD type II, or BD NOS as per the administration of the MINI Adult

Exclusion

Autism Spectrum Disorder (ASD)

Developmental Intellectual Disorder

Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)

Schizophrenia

Uncontrolled or severe medical problem per investigator judgment

For the offspring: parents with a history of any brain diseases, including seizures, stroke, meningitis, encephalitis, dementia, and other degenerative brain diseases; parents with a history of intellectual disability

Any Psychiatric Diagnosis

Any family history of Bipolar Disorder, Psychotic Disorder, Schizophrenia, or Schizoaffective disorder in a first-degree relative

Any family history of a neurological condition in a first-degree relative.

Mental Retardation/Intellectual Disability

Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)

Schizophrenia

Uncontrolled or severe medical problem per investigator judgement

Autism Spectrum Disorders (ASD)

Intellectual Developmental Disorder

Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)

Schizophrenia

Uncontrolled or severe medical problem per investigator judgement

What this trial measures

Positive Identification of Bipolar Disorder as Assessed by Mini-International Neuropsychiatric Interview for Children and Adolescents (MINI Kid 7.2) (child)baseline, annually until participant turns 25 years of age

Trialytics