Resilience Through Interventions for Successful Early Outcomes (ABC Parenting Program)
This study is looking at how a parenting program called Attachment and Biobehavioral Catch-up (ABC) affects stress in young children. The ABC program involves 10 home visits designed to help parents be more sensitive and nurturing. You might be able to join if you are a parent or legal guardian, aged 18 or older, speak English or Spanish, and have a child between 24 and 42 months old. Your child must live with you and have experienced social risk factors for adversity. The study will involve about 150 parent-child pairs. Participants will either receive the ABC program right away or after a 4-month wait. Researchers will measure children's inflammation and epigenetic age (a measure of biological aging) to see the program's effects.
- Study design
- This study is an interventional study with approximately 150 parent-child pairs. Participants will be randomly assigned to either receive the ABC program immediately or after a 4-month wait.
- What's involved
- Participants will either receive 10 sessions of the ABC parenting program or be on a 4-month waitlist before receiving the program. Child inflammation and epigenetic age will be measured at the beginning of the study and again 13-20 weeks later.
- Compensation
- Not stated in the trial record.
- Follow-up
- Children's inflammation will be measured at the start of the study and again 13-20 weeks after the start.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Resilience Through Interventions for Successful Early Outcomes
At a glance
Conditions
NCT06669624
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of North Carolina at Chapel Hill
Chapel Hill, South Carolinastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Danielle Roubinov, PhD · PRINCIPAL_INVESTIGATOR · University of North Carolina, Chapel Hill
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
Want this trial checked against your situation?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Inclusion
Exclusion
What this trial measures
- Child inflammationPre-intervention baseline
Pediatric saliva samples will be assayed for cytokine concentrations.
- Child inflammation13-20 weeks after baseline
Pediatric saliva samples will be assayed for cytokine concentrations.
- Child epigenetic age accelerationPre-intervention baseline
Pediatric buccal swabs will be assayed for DNAm, which will be used to calculate child epigenetic age
- Child epigenetic age acceleration13-20 weeks after baseline
Pediatric buccal swabs will be assayed for DNAm, which will be used to calculate child epigenetic age
- Child telomere lengthPre-intervention baseline
DNA will be extracted from child buccal swabs to calculated T/S ratios.
- Child telomere length13-20 weeks after baseline
DNA will be extracted from child buccal swabs to calculated T/S ratios.
- Child hair cortisolPre-intervention baseline
Several strands of hair will be collected and assayed to obtain hair cortisol concentration
- Child hair cortisol13-20 weeks after baseline
Several strands of hair will be collected and assayed to obtain hair cortisol concentration
- Child stress hormonesPre-intervention baseline
Child hair and saliva samples for cortisol, cortisone, DHEA, progesterone, and endocannabinoid levels to examine both cumulative and dynamic stress hormone responses.
- Child stress hormones13-20 weeks after baseline
Child hair and saliva samples for cortisol, cortisone, DHEA, progesterone, and endocannabinoid levels to examine both cumulative and dynamic stress hormone responses.
- ParentingPre-intervention baseline
Behavioral coding of parenting will be conducted using video recordings of tasks from the Early Regulation in Context Assessment.
- Parenting13-20 weeks after baseline
Behavioral coding of parenting will be conducted using video recordings of tasks from the Early Regulation in Context Assessment.
- Child wellbeingPre-intervention baseline
Caregiver reports of their child's quality of life will be obtained using the Pediatric Quality of Life (PedsQL) Inventory. Scores range from 0 to 100, with higher scores indicating better functioning.
- Child wellbeing13-20 weeks after baseline
Caregiver reports of their child's quality of life will be obtained using the Pediatric Quality of Life (PedsQL) Inventory. Scores range from 0 to 100, with higher scores indicating better functioning.
- Child executive functioningPre-intervention baseline
Child executive functioning will be assessed using the Minnesota Executive Function Scale™ The MEFS has been nationally normed based on the child's age and standardized scores are automatically generated using an algorithm that combines accuracy and response time (M = 100, SD = 15). Scores range from 60-140, with higher scores indicating better performance.
- Child executive functioning13-20 weeks after baseline
Child executive functioning will be assessed using the Minnesota Executive Function Scale™ The MEFS has been nationally normed based on the child's age and standardized scores are automatically generated using an algorithm that combines accuracy and response time (M = 100, SD = 15). Scores range from 60-140, with higher scores indicating better performance.
- Child mental healthPre-intervention baseline
Child mental health will be assessed using caregiver reports through the Child Behavior Checklist preschool-aged form (1.5-5). We will use the total, internalizing, and externalizing subscales, with scores ranging from 0-200, 0-72, and 0-48, respectively. Higher scores represent worse functioning.
- Child mental health13-20 weeks after baseline
Child mental health will be assessed using caregiver reports through the Child Behavior Checklist preschool-aged form (1.5-5). We will use the total, internalizing, and externalizing subscales, with scores ranging from 0-200, 0-72, and 0-48, respectively. Higher scores represent worse functioning.
- Caregiver anxietyPre-intervention baseline
Caregiver anxiety symptoms will be assessed using the Generalized Anxiety Disorder 7-item (GAD-7) scale. The total score ranges from 0-21, with higher scores indicating more severe anxiety.
- Caregiver anxiety13-20 weeks after baseline
Caregiver anxiety symptoms will be assessed using the Generalized Anxiety Disorder 7-item (GAD-7) scale. The total score ranges from 0-21, with higher scores indicating more severe anxiety.
- Caregiver depressionPre-intervention baseline
Caregiver depression symptoms will be assessed using the Patient Health Questionnaire-9 item form. Scores range from 0 to 27, with higher scores representing worse functioning.
- Caregiver depression13-20 weeks after baseline
Caregiver depression symptoms will be assessed using the Patient Health Questionnaire-9 item form. Scores range from 0 to 27, with higher scores representing worse functioning.