This study is looking at how starting testosterone (a hormone therapy) affects headaches and brain development in transmasculine youth (assigned female at birth, identifies as male). Researchers want to understand if testosterone changes headache patterns and brain structures like the amygdala (a part of the brain involved in emotions). You can join if you are 12-20 years old, assigned female at birth, identify as transmasculine or gender diverse, and plan to start testosterone within six months. If you are already on a puberty blocker, you must have started it at least three months ago. The study will track changes in your headache burden and amygdala volume over two years to see how testosterone impacts these areas.

Study design

This is an observational study, meaning researchers will watch and collect information without giving you any new treatments. About 100 participants are planned for this study.

What's involved

You would attend four visits over two years: before starting testosterone, and then at 6 months, 1 year, and 2 years after starting. These visits include physical exams, questionnaires, and brain imaging.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed for two years, with the final measurements taken at the end of this period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.