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NCT06671626

Intracranial Recordings to Characterize Action Regulation Mechanisms

Enrolling by Invitation
NAAges 18+InterventionalBasic science
University of Texas Southwestern Medical Center
~125 participants
Updated 2026-03-17 on ClinicalTrials.gov
What's tested:Subcortical Stimulation

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Cortical ECoG and Subcortical recordings
Measured over Intra-operative
+1 more outcome measured

Conditions

Parkinson Disease

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Parkinson Disease

Where it's being run

1 sites across 1 states
Texas1

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age 18 years or older.
Diagnosis of Parkinson's disease (rigid-akinetic subtype or tremor-dominant) based on presence of at least 2 cardinal PD features (tremor, rigidity, or bradykinesia).
Clinical indication and decision to proceed with subthalamic nucleus deep brain stimulation implantation.
L-dopa responsive with clearly defined "on" periods, with at least 30% improvement in UPDRS III scores on vs off medications (with documented ON UPDRS III scores).
Willingness and ability to cooperate during conscious operative procedure for up to 30 minutes.
Preoperative MRI without evidence of cortical or subdural adhesions or vascular abnormalities.

Exclusion

Patients with recent use (within one week) of anticoagulant or antiplatelet agent use.
Neurocognitive testing indicating amnestic cognitive deficits (MOCA \< 24).

What this trial measures

  • Cortical ECoG and Subcortical recordingsIntra-operative

    Cortical ECoG and subcortical LFP recordings will occur during DBS implantation surgery during the behavioral assessments

  • Behavioral assessmentIntra-operative

    Each patient will complete a task that assesses action regulation through a decision making, stopping, and switching task.