Back to search results

NPA-OSA Device Study for Obstructive Sleep Apnea

This study is looking into a new device called the NPA-OSA for adults with moderate to severe obstructive sleep apnea (OSA). The NPA-OSA is a soft, tube-like device that you insert into your nose before sleeping to help reduce snoring and sleep apnea. Researchers want to see if this device can lower the number of times your breathing stops or becomes very shallow during sleep (Apnea Hypopnea Index or AHI). You might be able to join if you are an adult with OSA, especially if you have difficulty using CPAP or are looking for other options. The study aims to enroll about 20 participants, but its current recruitment status is unclear.

Study design
This is an interventional pilot study, meaning participants will receive the NPA-OSA device. It plans to enroll about 20 adult participants.
What's involved
You would need to commit to and complete the study over a 30-day period. This includes a baseline measurement and another measurement at 30 days.
Compensation
Not stated in the trial record.
Follow-up
Your AHI will be measured at baseline and again at 30 days.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06677151

NPA-OSA Device Tolerability, Usability and Acclimation Clinical Study in Adult Obstructive Sleep Apnea (OSA) Patients

Recruiting
NAAges 18+InterventionalTreatment
University of Michigan
~20 participants
Updated 2026-03-12 on ClinicalTrials.gov
What's tested:nasopharyngeal airway obstructive sleep apnea (NPA-OSA) device

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in severity of apnea hypopnea index (AHI)
Measured over Baseline (day 0), 30 days

Conditions

Sleep Apnea, Obstructive

Explore related trials

Obstructive Sleep Apnea

Where it's being run

2 sites across 1 states
Michigan2

Study leadership

  • Louise M O'Brien, PhD · PRINCIPAL_INVESTIGATOR · University of Michigan

Who to contact

Zahra Nourmohammadi, PhD
[email protected]
734 936-9816
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Capacity and willingness to sign consent
Patient willingness to commit to and complete study over a 30-day time period
Confirmed diagnosis of moderate to severe OSA (AHI \>= 15)
OSA caused by upper airway obstruction
CPAP non-compliant where CPAP compliance is defined as using CPAP for at least 4 hours a night for at least 70% of nights or interest in an alternative sleep apnea therapy
Adequate manual dexterity to demonstrate ability to self-insert and remove device

Exclusion

Within 3 months of initiating CPAP use, and actively using CPAP
Supraglottic airway collapse
Distal airway stenosis
Tracheobronchomalacia
Currently pregnant
Active COVID-19 infection
Need for anticoagulative therapy
Severe nasal allergies
Bleeding disorder
More than mild elevation of End-tidal carbon dioxide (ETCO2) or total carbon dioxide (TCO2) values \>60 mmHg for \>10% of sleep time
Restrictive thoracic disorders
Silicone, lidocaine, neosynephrine allergy
Recurrent epistaxis
Uncontrolled or serious illness, included but not limited to: severe breathing disorders including hypercapnic respiratory failure, respiratory muscle weakness, bullous lung disease (as seen in some types of emphysema), bypassed upper airway, pneumothorax, pneumomediastinum, etc.; severe heart disease (including heart failure); or pathologically low blood pressure

What this trial measures

  • Change in severity of apnea hypopnea index (AHI)Baseline (day 0), 30 days

    The AHI is calculated by dividing the number of apnea events by the number of hours of sleep.