Swallowing Impairments in Adults With and Without Alzheimer's Disease

This research study is looking into how swallowing changes in adults with Alzheimer's disease (AD) compared to those without AD. We know that many people with moderate to severe AD have trouble swallowing, but we don't fully understand how these problems develop over time. This study aims to evaluate swallowing function in both groups. We are also involving primary caregivers of individuals with AD to understand how swallowing difficulties impact them. You may be able to join if you are an adult aged 60 or older, with or without an AD diagnosis confirmed by a neurologist. The main goal is to measure swallowing safety during a single visit.

Study design
This is an observational study planning to enroll 240 participants. It compares swallowing function in adults with and without Alzheimer's disease.
What's involved
You would have one in-person research visit lasting about 1 to 1.5 hours. This visit includes screening, cough and swallow function tests, hand grip and tongue strength assessments, and questionnaires.
Compensation
Not stated in the trial record.
Follow-up
Swallowing safety is measured during the baseline visit at the time of enrollment, so there is no specified follow-up period after this visit.

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NCT06678100

Swallowing Impairments in Adults With and Without Alzheimer's Disease

Recruiting
Not specifiedAges 60+Observational
Vanderbilt University Medical Center
~240 participants
Updated 2026-05-08 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Swallowing safety
Measured over During baseline visit at time of enrollment.
Alzheimer Disease
Caregiver Burden
Healthy Aging
Dysphagia
1 sites across 1 states
Tennessee1

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  • Swallowing safetyDuring baseline visit at time of enrollment.

    The penetration aspiration scale is a validated 8-point ordinal rating scale that measures the depth of airway invasion and the patient's response during swallowing. Scores range from 1 to 8 with a score of 1 indicating a safe swallow (best score) and 8 indicating silent aspiration (worst score).