This study is looking at whether giving Amiodarone Hydrochloride Injection earlier to people experiencing out-of-hospital cardiac arrest (when the heart suddenly stops beating) due to a specific heart rhythm (ventricular fibrillation or ventricular tachycardia) can improve how quickly the medication is given. Researchers want to see if giving Amiodarone after the second defibrillator shock, at the same time as epinephrine, is better than the usual care protocol, which gives Amiodarone after the third defibrillator shock. You could be eligible if you are 18 or older, have had a non-traumatic out-of-hospital cardiac arrest, and have a specific heart rhythm that doesn't respond to the first defibrillation. The main goal is to measure the time it takes to give Amiodarone. The study is currently unclear on its recruitment status and plans to enroll 585 participants.

Study design

This is a pilot, pragmatic stepped-wedge cluster randomized trial involving 585 planned participants. It compares two different treatment approaches for cardiac arrest.

What's involved

Not specified in the trial record.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint, time to amiodarone delivery, is measured at up to 1 day. Other outcomes like survival to hospital discharge will also be evaluated.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.