Quercetin for Microvascular Function in Obesity

This study is looking at how a dietary supplement called Quercetin might affect the health of your smallest blood vessels (microvasculature). Researchers want to see if taking Quercetin daily for 30 days can improve how well these tiny blood vessels expand. You might be able to join if you are between 18 and 40 years old, speak English, and have obesity (a BMI over 30). The study aims to find out if Quercetin makes a difference in blood vessel dilation, which is measured after 2 hours. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 40 participants. Participants will be randomly assigned to receive either Quercetin or a placebo (a sugar pill).
What's involved
You would take one Quercetin pill per day for 30 days. You would also have two blood draws, a camera placed under your tongue to view blood vessels, and two catheters placed on your forearm to monitor blood vessels.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome measures changes in blood vessel dilation at 2 hours.

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NCT06683534

Palmitic Acid and Human Microvascular Function

Not Yet Recruiting
PHASE2Ages 18–40InterventionalBasic science
Medical College of Wisconsin
~40 participants
Updated 2026-04-29 on ClinicalTrials.gov
What's tested:Quercetin (dietary supplement)Placebo

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in blood vessel dilation
Measured over 2 hours
Microvascular Dysfunction
Microvasculature
Cardiovascular Diseases
Cardiovascular Diseases (CVD)
Microvascular Health
Obesity and Overweight
1 sites across 1 states
Wisconsin1

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Eligibility criteria

Inclusion

Obesity (BMI\>30)
Aged 18-40 years
English Speaking

Exclusion

BMI\>60
Resting SBP ≥180 mmHg or DBP ≥ 110mmHg
Pregnancy or breastfeeding.
Prior history of myocardial infarction
Diagnosis of more than 1 risk factor for coronary artery disease (active smoker, diabetes mellitus- type 1 or 2, congestive heart failure, hyperlipidemia, hypertension)
Active mouth sores that affect the buccal mucosa.
  • Change in blood vessel dilation2 hours

    Peripheral microvascular dilation in response to acetylcholine, L-NAME, and sodium nitroprusside infusions will be measured using laser Doppler flowmetry with microdialysis.