Observational Study on Alcohol Use and Oral Health
This observational study is looking at how heavy alcohol use affects your mouth and overall health. People with alcohol use disorder (AUD) often have more dental and gum problems, which can lead to other health issues like diabetes or stroke. Researchers want to understand how to spot early signs of inflammation in the mouth and how better oral hygiene can help people with AUD. The study has two main goals: to test a new questionnaire about oral health behaviors and to learn more about how these behaviors impact inflammation in people with AUD. You can join if you are 18 or older, are being treated for AUD, and can speak English. Healthy volunteers are also needed. The study is currently recruiting 72 participants.
- Study design
- This is an observational study involving 72 participants. It is designed to explore the links between oral health, behaviors, and biological markers in people with alcohol use disorder and healthy individuals.
- What's involved
- You will have at least two visits if you have AUD, or one dental visit if you are a control. These visits will involve collecting saliva, mouthwash, and blood samples, as well as dental exams and filling out questionnaires.
- Compensation
- Not stated in the trial record.
- Follow-up
- The study measures outcomes when recruitment and sample processing are complete, and until the primary endpoint of cognitive interviews is reached.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
The Impact of Heavy Alcohol Use on Saliva and Oral Health
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Katherine A Maki, C.R.N.P. · PRINCIPAL_INVESTIGATOR · National Institutes of Health Clinical Center (CC)
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Completion of a total of 12 cognitive interviews in participants with AUD (n=6) & healthy participants (n=6). Editing of any language in the OHBA (if applicable) as a result of the cognitive interviewing results.Until endpoint is reached.
The endpoint will refine the OHBA questionnaire, if needed, to improve subject understanding and acceptability of the questions in the instrument; a primary measure in the Part 2 portion of the current study.
- Feasibility of saliva biomarker quantification measured after 2 visits in patients with AUD and one dental visit in controls.When recruitment and sample processing is complete.
This endpoint will identify if salivary samples are appropriate to measure inflammation and stress-associated biomarkers in patients with AUD, if special procedures need to be performed to quantify salivary biomarkers in patients with AUD and the identification of other variables that may influence salivary samples in patients with AUD for future research consideration.
- Quantification of oral health behaviors, oral health, clinical symptoms, salivary characteristics, and salivary and blood biomarker levels in patients with AUD and controls at dental exam visit.When recruitment and sample processing is complete.
The endpoints will be measured to evaluate relationships between potential salivary signaling biomarkers and multiple facets of oral and systemic health and health behaviors.