Incentive Spirometry for Lung Cancer Patients Undergoing Chemo and Radiation

This study is looking at whether using an incentive spirometer, a device that helps you take deep breaths, can reduce lung problems in people with advanced non-small-cell lung cancer. These patients are also receiving chemotherapy and radiation therapy, and may receive immunotherapy. The study wants to see if using the spirometer 10 times every hour you're awake can lower the chance of developing lung inflammation (pneumonitis) and improve your overall survival and quality of life. You might be able to join if you have advanced non-small-cell lung cancer, are eligible for chemotherapy and radiation, and are at least 18 years old. The study will measure how many people develop pneumonitis within 12 months.

Study design
This is a pilot study involving 100 participants. It is an interventional study, meaning participants will receive a specific intervention.
What's involved
You will use an incentive spirometer 10 times every hour you are awake, daily during treatment and for up to three months after treatment. You will also complete quality of life assessments at the start, and at 3, 6, and 12 months.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, incidence of pneumonitis, will be measured at 12 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06688422

Incentive Spirometry to Improve Outcomes in Lung Cancer Patients Undergoing Concurrent Chemotherapy and Radiation Therapy

Recruiting
NAAges 18+InterventionalSupportive care
The Cooper Health System
~100 participants
Updated 2026-04-15 on ClinicalTrials.gov
What's tested:incentive spirometry

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incidence of Pneumonitis
Measured over 12 months
Lung Cancer
Pneumonitis
Radiation-Induced Lung Injury
Immunotherapy-Induced Pneumonitis
Non-Small-Cell Lung Cancer (NSCLC)
1 sites across 1 states
New Jersey1

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Confirmed diagnosis of advanced non-small-cell lung cancer
Performance status (ECOG 0-1)
Eligible for concurrent chemotherapy and radiation
18 years or older

Exclusion

Previous lung or thoracic surgery
Enrollment in another pulmonary intervention trial
Home oxygen usage prior to enrolment
Radiological evidence of pleural effusion, pneumothorax, bullous emphysema, - or pneumonitis on staging imaging
Presence of active respiratory tract infection
Uncontrolled nausea and vomiting
Prior exposure to drugs such as amiodarone, bleomycin, or immunotherapy
Inability or unwillingness of individual to give written informed consent
  • Incidence of Pneumonitis12 months

    Primary Endpoint: To determine the impact of incentive spirometry on the incidence of pneumonitis. Assessment Method: Number of participants diagnosed with pneumonitis, assessed using CT scan and clinical diagnostic criteria