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E-cigarette Cessation for Adults Who Also Use Cannabis

This study is looking at how well a medication called varenicline (often used to help people stop smoking cigarettes) works for adults who want to quit e-cigarettes and also use cannabis. All participants will receive varenicline pills for 12 weeks, along with financial rewards for staying off e-cigarettes and counseling. To join, you must be between 18 and 40 years old, use e-cigarettes daily or almost daily, and also use cannabis. You must also be interested in quitting e-cigarettes and willing to take varenicline. The study will measure success by seeing how many participants have not used tobacco in the last 7 days of the 12-week treatment. The current recruitment status is unclear, but 105 people are planned to enroll.

Study design
This is an interventional study where all 105 participants will receive the same treatment, including varenicline, behavioral therapy, and counseling.
What's involved
You would take varenicline pills for 12 weeks, attend weekly visits to receive financial incentives for e-cigarette abstinence, and participate in psychosocial counseling.
Compensation
Financial incentives will be provided at weekly visits if you are abstinent from e-cigarettes.
Follow-up
The main success of the study is measured at the end of the 12-week treatment period.

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NCT06688539

E-cigarette Cessation in Adults Who Co-use Cannabis

Recruiting
PHASE4Ages 18–40InterventionalTreatment
Medical University of South Carolina
~105 participants
Updated 2026-06-12 on ClinicalTrials.gov
What's tested:Varenicline PillContingency managementCounseling

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
7-day point prevalence tobacco abstinence at the end of treatment (Week 12)
Measured over Final 7 days of treatment (Week 12)

Conditions

Nicotine Dependence
Tobacco Use Disorder

Explore related trials

Nicotine DependenceTobacco Use Disorder

Where it's being run

3 sites across 1 states
South Carolina3

Study leadership

  • Erin A McClure, PhD · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina

Who to contact

Elizabeth Chapman, MA, LPC, LAC, AADC
[email protected]
864.898.2992
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Eligibility criteria

Inclusion

Between the ages of 18 and 40 years old
Use e-cigarettes daily or near daily in the past month
Must submit a positive instant-read urine cotinine test at screening (≥ 200 ng/ml)
Be interested in quitting use of e-cigarettes
Must be willing to take varenicline for the standard 12-week course of treatment
Self-reported use of cannabis on at least 10 out of the past 30 days or must submit a positive qualitative urinary cannabinoid test at screening (\> 50 ng/ml)

Exclusion

Any serious or unstable medical/psychiatric disorder (including severe substance use disorders, other than cannabis or tobacco use disorders) in the past three months that may interfere with study performance
Use of cigarettes on 10+ days in the past 30
Currently pregnant or breastfeeding
Current use of medications with smoking cessation efficacy
Use of any medications that would interfere with varenicline

What this trial measures

  • 7-day point prevalence tobacco abstinence at the end of treatment (Week 12)Final 7 days of treatment (Week 12)

    7-day point prevalence abstinence from e-cigarettes at the end of treatment (Week 12) will be assessed via biochemical verification (urinary cotinine; ng/ml) and will be compared to cigarette abstinence rates from the parent study (as historical controls)