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Study on Exercise, Gut Health, and Body Type in Women

This study is looking at how a single 30-minute workout affects the 'gut bugs' (gut microbiome) in women. Researchers want to understand if this exercise changes the types of bacteria in your gut and what they do, as well as other substances in your blood. They are comparing women with different fitness levels and body types (some with obesity, some without). The study is currently unclear on its recruitment status and aims to enroll 40 women between 21 and 40 years old. To be eligible, you must be a woman with a BMI between 19-24.99 or 30-40, and exercise at least 4 times a week for 60 minutes each time.

Study design
This interventional study plans to enroll 40 women to examine the effects of a single exercise session. The phase of the study is not specified.
What's involved
You would have three in-person visits. These include health checks, body scans, strength and endurance tests, blood draws, and a 30-minute cycling exercise. You will also collect a stool sample at home and track your diet.
Compensation
Not stated in the trial record.
Follow-up
Your gut microbiome and blood substances will be measured immediately after the exercise, and blood will also be measured 24 hours before the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06691100

How a Single Workout Affects Gut Bugs in Women With Different Fitness Levels and Body Types

Recruiting
NAAges 21–40InterventionalPrevention
George Washington University
~40 participants
Updated 2025-07-24 on ClinicalTrials.gov
What's tested:Aerobic Exercise

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Gut Microbiome Composition
Measured over Before the exercise intervention and immediately after the intervention
+3 more outcomes measured

Conditions

Weight Management
Obesity
Exercise
Women
Gut Microbiome
Metabolome
Health
Gut Microbiota

Explore related trials

Obesity

Where it's being run

1 sites across 1 states
District of Columbia1

Who to contact

Carmen Ortega-Santos, PhD, RD
[email protected]
2029942757
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Biological sex: female
BMI 19 to 24.99 kg/m2 or BMI 30-40 kg/m2
Exercisers: Exercise at least 4 times per week for 60 minutes (a total of 240 minutes per week) on a programmed exercise training either on endurance sports (e.g., running, cycling, triathlon), strength (e.g., powerlifting), or team sports (e.g., rugby, football, soccer)
Non-Exercisers: Sedentary individuals who have not reached the PA guidelines (150 minutes of moderate-intensity physical activity a week, 75 minutes of vigorous-intensity physical activity, or an equivalent combination of moderate and vigorous-intensity physical activity).

Exclusion

Biological sex: male
BMI \< 19 kg/m2 or \> 40 kg/m2
Currently pregnant, \< 2 years postpartum, lactating
Currently taking any herbal, fiber, or prebiotic supplement
Current or 1-month before the study, taking oral or vaginal antibiotics
Diagnosed with any gastrointestinal, endocrine, digestive, cancer, or cardiovascular disease.

What this trial measures

  • Gut Microbiome CompositionBefore the exercise intervention and immediately after the intervention

    Shotgun metagenomics will be used to examine the abundance of specific SCFA-producing bacteria in the stool (e.g., Ruminococcus)

  • Gut Microbiome FunctionBefore the exercise intervention and immediately after the intervention

    Shotgun metagenomics will be used to examine the BGCs (i.e., the genes within the microbial genome that dictate gut microbial functionality) to investigate functional downstream metabolic activity.

  • Plasma MetabolomeBefore the exercise intervention, immediately after the exercise intervention, and 24 hours before the intervention

    Gas chromatography and mass spectrometry will be used to measure concentrations of SCFAs in plasma before and after the exercise intervention

  • Stool MetabolomeBefore the exercise intervention, immediately after the exercise intervention, and 24 hours before the intervention

    Gas chromatography and mass spectrometry will be used to measure concentrations of SCFAs in stool before and after the exercise intervention