Vaginal Changes After CO2 Laser for Genitourinary Syndrome of Menopause

This study is looking at how CO2 laser treatment affects the vagina in women with Genitourinary Syndrome of Menopause (GSM). GSM is a condition caused by lower estrogen levels after menopause, leading to symptoms like vaginal dryness and painful intercourse. The CO2 laser is being explored as a non-hormonal treatment option for these symptoms. Researchers will use a special device called Optical Coherence Tomography (OCT) to measure changes in vaginal tissue, specifically vaginal epithelial thickness and blood vessel density. They want to see if the CO2 laser helps improve these measurements. You can join if you are a woman aged 18 or older, have GSM, and are willing to use vaginal laser therapy without other GSM treatments during the study. The study plans to enroll 50 participants, but its current recruitment status is unclear.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 50 women.
What's involved
Measurements will be taken once a month for the first three months, then every three months for one year. This involves using an OCT device in the vaginal canal.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for one year after the initial three months of monthly measurements.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06691178

Vaginal Changes After CO2 Laser

Recruiting
NAAges 18+InterventionalTreatment
University of California, Irvine
~50 participants
Updated 2026-02-18 on ClinicalTrials.gov
What's tested:Optical coherence tomography (OCT)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Vaginal epithelial thickness
Measured over Measurements will be obtained once a month for the first three months. Measurements will be obtained at subsequent follow up visits every 3 months for 1 year.
+1 more outcome measured
Genitourinary Syndrome of Menopause

NCT06691178

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Beckman Laser Institute

    Irvine, Californiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Felicia Lane, MD · PRINCIPAL_INVESTIGATOR · University of California, Irvine

Opens a ready-to-send draft in your own email app — review before sending.

  • Vaginal epithelial thicknessMeasurements will be obtained once a month for the first three months. Measurements will be obtained at subsequent follow up visits every 3 months for 1 year.

    OCT measurement of vaginal epithelial thickness

  • Blood vessel densityMeasurements will be obtained once a month for the first three months. Measurements will be obtained at follow up visits every 3 months for 1 year.

    OCT measurement of blood vessel density