Comparing Ticagrelor and Prasugrel Monotherapy After PCI

This study is comparing two anti-clotting medications, ticagrelor (90 mg) and prasugrel (10 mg), when used alone after a procedure called PCI (percutaneous coronary intervention) for coronary artery disease. If you've been on dual antiplatelet therapy (DAPT) with aspirin plus either prasugrel or ticagrelor for at least 90 days after PCI, and are between 18 and 75 years old, you might be able to join. The study wants to see if these two medications, when used alone, have similar effects on your platelets (tiny blood cells involved in clotting). The goal is to determine if prasugrel monotherapy is as effective as ticagrelor monotherapy in controlling platelet activity. The current status of this study is unclear, and it plans to enroll 48 participants.

Study design
This is an interventional study where participants will be randomly assigned to receive either ticagrelor or prasugrel monotherapy. It plans to enroll 48 participants.
What's involved
After providing consent, you would stop taking aspirin and be assigned to take either ticagrelor 90 mg twice a day or prasugrel 10 mg once a day. Platelet reactivity will be measured around 21 days later.
Compensation
Not stated in the trial record.
Follow-up
Platelet reactivity will be measured at 21 ± 7 days after starting the new medication.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06691191

Switching From Dual Antiplatelet Therapy to Monotherapy With Potent P2Y12 Inhibitors

Recruiting
PHASE4Ages 18–75InterventionalTreatment
University of Florida
~48 participants
Updated 2026-02-05 on ClinicalTrials.gov
What's tested:Ticagrelor 90 mgPrasugrel 10 mg

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Platelet reactivity measured by VerifyNow
Measured over 21±7 days
Coronary Artery Disease
1 sites across 1 states
Florida1
  • Francesco Franchi, MD · PRINCIPAL_INVESTIGATOR · University of Florida College of Medicine Jacksonville

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  • Platelet reactivity measured by VerifyNow21±7 days

    The primary endpoint of the study is the comparison of P2Y12 reaction unites (PRU) levels determined by VerifyNow between prasugrel monotherapy and ticagrelor monotherapy