This study is testing if semaglutide, a medication, is safe and well-tolerated for adults with cocaine use disorder (CUD), including those who also have HIV. You would be between 18 and 65 years old, have CUD, and have used cocaine recently. The study aims to see if semaglutide can help with cocaine use outcomes and improve heart and inflammation markers. You would receive either semaglutide or a placebo (an inactive substance) once a week for 16 weeks. The main goals are to check the safety and how well semaglutide is tolerated over this period. The study is currently recruiting about 40 participants.

Study design

This is a 16-week, double-blind (neither you nor your doctor will know if you're getting the active drug or placebo), placebo-controlled study involving about 40 participants.

What's involved

You would visit the clinic weekly for injections and every two weeks for lab work, assessments, and surveys. You may also complete two optional MRI scans.

Compensation

Not stated in the trial record.

Follow-up

A final assessment will be completed at Week 16, which is the end of the study period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.