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NCT06693544

Peanut Sip Feeding Protocol

Enrolling by Invitation
NAAges 65–80Interventional
Texas A&M University
~15 participants
Updated 2025-11-21 on ClinicalTrials.gov
What's tested:Peanut protein

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Protein synthesis capacity of plant-based in older adults without sarcopenia measured by the use of stable isotope tracers
Measured over 2 weeks

Conditions

Protein Metabolism

Explore related trials

Sarcopenia

Where it's being run

1 sites across 1 states
Texas1

Study leadership

  • Marielle Engelen, PhD · PRINCIPAL_INVESTIGATOR · Texas A&M University

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Previous completion of IRB2023-0549: Prandial Metabolic Phenotyping in Sarcopenic Older Adults Comparing Plant Based and Whey Based Protein (NCT06628349)
Age 65-80 years old
Stable body-weight (less than ±5% in the previous 6 months)
Ability to walk, sit down, and stand up (independently or with walking assistance device)
Willingness to lay supine in bed for up to 6 hours
Willingness and ability to comply with the protocol

Exclusion

Established diagnosis and active treatment of chronic disease: Insulin dependent diabetes mellitus, active malignancy, heart disease, kidney disease, liver disease, HIV/AIDS, Asthma (moderate to severe), Hep (A,B, or C)
History of untreated metabolic disease including hepatic or renal disorder
Presence of acute illness or metabolically unstable chronic illness
Active dependence of alcohol or drugs
Use of short course of oral corticosteroids within 4 weeks preceding study day
Current use of long-term oral corticosteroids
Use of protein or amino acids containing nutritional supplements within 5 days of the first study day
Planned elective surgery requiring 2 or more days of hospitalization during the entire study
(Possible) pregnancy
Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject
Already enrolled in another clinical trial
Any condition according to the PI or nurse that was found during the screening visit, that would interfere with the study or safety of the patient
Known allergy to any of the components of the feeding (i.e., peanut)
Experienced issue with intake of peanut or peanut products within the previous year
Established daily diet of vegetarian / vegan composition

What this trial measures

  • Protein synthesis capacity of plant-based in older adults without sarcopenia measured by the use of stable isotope tracers2 weeks

    A novel stable isotope technique will be used to assess simultaneously the anabolic response and whole-body production rates of protein synthesis when taking oral nutrition in sarcopenic older participants. The samples will be stored in laboratory freezers and the amino acid isotope enrichments and concentrations analyzed by Liquid Chromatography with tandem mass spectrometry (LC-MS/MS). The researchers will then conduct LC-MS/MS analysis, peak integration, calculation of amino acid concentrations and whole body productions from raw data, and use the results for preparation of papers for presentation, publication, and final reports. The researchers main hypothesis is that plant-based protein induces less protein anabolism, due to lower whole body production of essential amino acids (EAA) and higher production of non-essential amino acids (NEAA).