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Oregano and Drug Interactions Study

This study is looking at how the dietary supplement oregano (oil of oregano, 180 mg softgel) might affect how your body handles certain medications. Researchers will give participants a "drug cocktail" containing common medicines like caffeine, dextromethorphan, losartan, midazolam, and omeprazole. The main goal is to see how oregano changes the levels of midazolam in your blood over 24 hours. This study is for healthy adults aged 18 to 64 who are not taking other medications or supplements that could interfere. The study is currently recruiting 16 participants.

Study design
This is an interventional study with 16 planned participants, but the phase is not specified. It is not stated if it is randomized or blinded.
What's involved
You would need to abstain from certain dietary/herbal supplements, citrus juices, cannabis, hemp, and THC/CBD products for several weeks.
Compensation
Not stated in the trial record.
Follow-up
Midazolam levels will be measured for 24 hours after administration.

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NCT06693960

Evaluating the Pharmacokinetics of Oregano and Potential Oregano-drug Interactions Using a Drug Cocktail Approach

Recruiting
EARLY_PHASE1Ages 18–64InterventionalBasic science
Washington State University
~16 participants
Updated 2026-06-04 on ClinicalTrials.gov
What's tested:OreganoDrug cocktail

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Midazolam Area under the plasma concentration vs. time curve (AUC) ratio
Measured over 0-24 hours

Conditions

Interaction

Explore related trials

Healthy Volunteer

Where it's being run

1 sites across 1 states
Washington1

Who to contact

Mary F Paine, RPh, PhD
[email protected]
509-358-7759
Email the study team

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Eligibility criteria

Inclusion

Between 18-64 years old and healthy
Not taking any medications (prescription and non-prescription) or dietary/herbal supplements that can interfere with study drug pharmacokinetics
Willing to abstain from consuming dietary/herbal supplements and citrus juices for several weeks
Willing to abstain from cannabis/marijuana, hemp, and THC- and CBD-containing products for several weeks
Willing to abstain from consuming caffeinated beverages or other caffeine-containing products the evening before and the morning of the first day of each study arm
Willing to abstain from consuming any alcoholic beverages for at least 1 day prior to any study day and during the study day
Willing to use a secondary method of birth control that does not include the introduction or discontinuance of hormonal-based birth control (such as abstinence, copper IUD, or condoms). Specifically, regardless of the use hormonal-based birth control, a non-hormonal method should be used for the duration of the study and for three weeks following cessation of participation.
Willing to abstain from consuming oregano (as a food additive or otherwise) for the duration of the study
Geographically located within a 40-mile radius of Spokane and have the time to participate

Exclusion

Under 18 or over 64 years old
Taking medications or dietary/herbal supplements that can interfere with study drug pharmacokinetics
Have a major illness
Taking medication/supplements for a mineral deficiency
History of intolerance or allergy to oregano or any of the cocktail drugs (caffeine, dextromethorphan, losartan, midazolam, and omeprazole)
Use of cannabis/marijuana, hemp, and CBD- and/or THC-containing products within the last month
Currently using drugs or illicit substances for recreational purposes
Pregnant or nursing
Geographically located outside the 40-mile radius of Spokane and do not have the time to participate
Cannot read and speak English

What this trial measures

  • Midazolam Area under the plasma concentration vs. time curve (AUC) ratio0-24 hours

    Ratio of the area under the plasma concentration vs. time curve of midazolam in the presence to absence of oregano.