This study, called the Antibiotic Concentrations After MassivE Transfusion Study, is looking at how blood transfusions might change the levels of antibiotics in your body if you've experienced a trauma. Researchers want to understand if receiving a lot of blood (a "massive transfusion") affects how well antibiotics like ampicillin/sulbactam, cefazolin, or others work. They will measure the amount of these antibiotics in your blood over the first 18 hours after you receive them. This study is for trauma patients aged 18 and older who are receiving one of the listed antibiotics and are either hospitalized or expected to be. The goal is to see how much of the drug is present in your blood. The current recruitment status is unclear, but the study plans to enroll 417 participants.

Study design

This is an observational study, meaning researchers will watch and collect information without giving you a specific treatment. It will compare trauma patients who receive a lot of blood transfusions to those who receive minimal or no transfusions.

What's involved

If you participate, blood samples (about 1mL each) will be collected at six specific times after you receive antibiotics. These collections will often happen at the same time as other blood draws to minimize extra needle sticks.

Compensation

Not stated in the trial record.

Follow-up

Your drug concentrations will be measured within the first 18 hours, and data will be collected until 30 days after your initial enrollment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.