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ReadMap: Understanding Reading After Stroke and in Aging

This study, called ReadMap, aims to better understand how the brain processes reading in people who have lost reading ability due to a stroke (alexia) and in typical older adults. Alexia can make everyday tasks like reading emails or signs very difficult. Researchers will conduct behavioral tests and brain imaging (MRI) to learn more about the brain and thinking processes involved in reading. You might be able to join if you are at least 18 years old and learned English by age 8. Stroke survivors who meet these criteria are welcome, as are healthy adults. The study will measure brain activity using MP-RAGE and DTI scans, and assess reading, speech, language, and thinking abilities. The goal is to improve diagnosis and treatment for reading difficulties.

Study design
This is an observational study involving up to 300 participants. It compares stroke survivors with alexia to typical older adults.
What's involved
You will complete a series of tests for reading, speech, language, and thinking. Some participants will also have an MRI scan.
Compensation
Not stated in the trial record.
Follow-up
Brain imaging and behavioral testing will be collected within one month of each other.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06700005

ReadMap: Reading in Stroke Alexia and Typical Aging

Recruiting
Not specifiedAges 18+Observational
Georgetown University
~300 participants
Updated 2024-11-21 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
MP-RAGE (Magnetization Prepared Rapid Acquisition Gradient Echo)
Measured over Collected within 1 month of behavioral testing
+2 more outcomes measured

Conditions

Aphasia
Stroke
Alexia

Explore related trials

AlexiaAphasiaBrain InjuryStroke

Where it's being run

1 sites across 1 states
District of Columbia1

Study leadership

  • Peter Turkeltaub, MD,PhD · PRINCIPAL_INVESTIGATOR · Georgetown University; MedStar National Rehabilitation Hospital

Who to contact

Alycia Laks, MS, CCC-SLP
[email protected]
202-687-5205
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age \>= 18
Learned English at 8 years or younger
Brain injury resulting from stroke
Age \>= 18
Learned English at 8 years or younger

Exclusion

History of other brain disorder that could interfere with our ability to interpret results (e.g., Multiple sclerosis, dementia, head injury causing loss of consciousness)
Severe psychiatric condition that would interfere with participation in the study
History of diagnosed learning disorder
Hearing or vision loss that interferes with performance on behavioral tests even after correction with glasses/hearing aids.
Inability to follow study procedures despite maximal support
Presence of metal in the body that is incompatible with MRI
Pregnancy
Claustrophobia

What this trial measures

  • MP-RAGE (Magnetization Prepared Rapid Acquisition Gradient Echo)Collected within 1 month of behavioral testing

    Part of MRI sequence that measures deep grey matter structure.

  • DTI (Diffusion Tensor Imaging)Collected within 1 month of behavioral testing

    Part of MRI sequence that measures the rate of water diffusion between cells to understand and create a map of internal structures.

  • Behavioral testingCollected within 1 month of MRI

    Battery of standard clinical and in-house behavioral tests to measure speech, language, and cognition. Final score is derived from principle components analysis.