Evaluating Clomid Protocols for Infertility Treatment

This study is for women with infertility who are undergoing in-vitro fertilization (IVF) and have diminished ovarian reserve. It compares two ways of using Clomiphene Citrate (Clomid) for ovarian stimulation: a standard 5-day protocol and a longer protocol. Clomid works by helping your body release more follicle-stimulating hormone (FSH), which encourages your ovaries to produce eggs. The longer Clomid protocol aims to stimulate the ovaries more intensely, potentially reducing costs and the number of injections you need. Researchers want to see if the longer Clomid protocol results in a higher number of mature eggs retrieved. You would be randomly assigned to one of the two Clomid groups. To join, you must be a woman between 18 and 45 years old, meet specific criteria for ovarian reserve (POSEIDON criteria), and be planning a 'freeze-all' cycle or a fresh transfer if in the short Clomid group. The study is currently unclear on its recruitment status.

Study design
This is an interventional study planning to enroll 120 women. Participants will be randomly assigned to receive either the long Clomid protocol or the standard 5-day Clomid protocol.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The number of mature oocytes will be measured up to 1 month after the study is completed.

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NCT06701071

Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian Stimulation

Recruiting
PHASE4Ages 18–44InterventionalTreatment
University of Southern California
~120 participants
Updated 2026-08-04 on ClinicalTrials.gov
What's tested:Clomiphene Citrate

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of mature oocytes
Measured over Up to 1 month after study completion
Infertility, Female
1 sites across 1 states
California1

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Eligibility criteria

Inclusion

Undergoing IVF
Must meet POSEIDON criteria based on clinic evaluation
Female partner: Antral follicle count of 2 or more and age \<45 at time of stimulation start
Male partner/sperm source: Cannot be azoospermic
Planning freeze-all cycle (regardless of blastocyst or cleavage stage culture) or fresh transfer if randomized to short Clomid group
Planning 36-hour trigger window

Exclusion

Normal ovarian reserve or good response
Allergy or adverse reaction to Clomid
Minimal stimulation protocols
History of prior premature ovulation
  • Number of mature oocytesUp to 1 month after study completion

    The number of mature oocytes retrieved at oocyte retrieval