Cervical Epidural Spinal Cord Stimulation for Functional Recovery

This study is exploring how cervical epidural spinal cord stimulation (EES) can help people with cervical spinal cord injury (SCI), tetraplegia (paralysis affecting all four limbs), or cervical myelopathy (spinal cord compression in the neck) regain arm and hand function. Researchers will place electrodes on the spinal cord during surgery to understand which stimulation patterns best activate arm and hand muscles. The goal is to find the most effective and precise ways to use EES. You may be able to join if you are 18 or older and have a clinical reason for cervical spine surgery. The study is currently unclear on its recruitment status and aims to enroll 36 participants.

Study design
This interventional study plans to enroll 36 participants. It is not specified if it is randomized or blinded.
What's involved
The study involves a surgical procedure to place spinal cord electrodes. During this procedure, researchers will test different stimulation settings.
Compensation
Not stated in the trial record.
Follow-up
The primary outcomes of the study are measured during the experiment, specifically 0-100 milliseconds after each stimulation event.

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NCT06701422

Targeting Cervical Epidural Spinal Cord Stimulation for Functional Recovery

Recruiting
NAAges 18+InterventionalBasic science
Columbia University
~36 participants
Updated 2025-11-24 on ClinicalTrials.gov
What's tested:Intraoperative stimulation of the cervical spinal cord

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Efficacy of epidural SCS
Measured over 0-100 milliseconds after each stimulation event during the experiment
+1 more outcome measured
Cervical Spinal Cord Injury
Tetraplegia/Tetraparesis
Cervical Myelopathy
2 sites across 1 states
New York2

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  • Efficacy of epidural SCS0-100 milliseconds after each stimulation event during the experiment

    Efficacy of stimulation is calculated as 1/threshold for provoking an motor evoked potentials. The threshold will be calculated from the recruitment curves.

  • Selectivity of epidural SCS0-100 milliseconds after each stimulation event during the experiment

    Selectivity is calculated from the recruitment curves of the target muscle compared to non-targeted muscles.