This study is looking at how social connection affects the brain. Researchers want to understand the link between social isolation, loneliness, and the density of synapses (connections between brain cells) using PET scans with a special tracer called [18F]SDM-8. To join, you must be 55 or older, able to speak English, and give written consent. You cannot have certain conditions that would prevent an MRI scan, like claustrophobia or metal in your body. The study will measure social disconnection and SV2A density (a marker for synapses) over about one year. The current recruitment status is unclear.

Study design

This is an observational study planning to enroll 100 participants. It is not a treatment study but rather observes existing conditions.

What's involved

You would have an MRI or fMRI scan, a PET scan, an MRS scan, an EEG, and follow-up phone calls every 3 months for 9 months, plus an in-person visit at 1 year.

Compensation

Not stated in the trial record.

Follow-up

You will have follow-up phone calls for 9 months and an in-person follow-up appointment 1 year after your scans.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.