Dietary Phosphorus and Calcium Balance in Moderate CKD

This study is looking at how different amounts of phosphorus in your diet affect the balance of phosphorus and calcium in your body if you have moderate chronic kidney disease (CKD). Researchers want to understand if eating a low-phosphorus diet (LP) versus a high-phosphorus diet (HP) changes how your body handles these important minerals. You might be able to join if you are 30-75 years old, have moderate CKD (eGFR category 3b or 4), and your parathyroid hormone levels are above normal. The study aims to see how phosphorus and calcium balance is affected over 5 days. The current recruitment status is unclear, and 14 people are planned to enroll.

Study design
This is an interventional study with 14 participants. You would be randomly assigned to follow either a low-phosphorus diet then a high-phosphorus diet, or vice versa.
What's involved
Each diet phase lasts 19 days, including 7 days at home, 5 days staying at a clinic for controlled diet and tests, and another 7 days at home.
Compensation
Not stated in the trial record.
Follow-up
The primary outcomes of phosphorus and calcium balance are measured over 5 days.

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NCT06712719

Effects of Dietary Phosphorus on Phosphorus and Calcium Whole-Body Balance and Kinetics in Moderate CKD

Not Yet Recruiting
NAAges 30–75InterventionalBasic science
University of Minnesota
~14 participants
Updated 2026-07-10 on ClinicalTrials.gov
What's tested:LP then HPHP then LP

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Phosphorus Balance
Measured over 5 days
+1 more outcome measured
CKD
1 sites across 1 states
Indiana1
  • Kathleen Hill Gallant, PhD · PRINCIPAL_INVESTIGATOR · University of Minnesota

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Eligibility criteria

Inclusion

Men or women, ages 30-75 years old, any race or ethnicity
Moderate CKD, defined by KDIGO as eGFR category 3b (30-44 mL/min) or 4 (16-29 mL/min) with albuminuria categories A1-A3
Serum intact parathyroid hormone above assay normal limit
Female subjects must be postmenopausal (\>12 months since last menstrual period), surgically sterile, or confirmed not pregnant by pregnancy test

Exclusion

Willing to discontinue supplements (e.g., vitamin D, calcium, multivitamin/minerals, or others) upon enrollment until completion of the study
Adequate vitamin D status defined as serum 25D \> 20 ng/mL based on National Academy of Medicine (then Institute of Medicine) criteria.
Plans to initiate dialysis within 6 months
Hypercalcemia defined as corrected serum calcium \>9.8 mg/dL within past 3 months
Hyperkalemia defined as serum potassium \>5.5 mg/dL within past 3 months
Hyperphosphatemia defined as serum phosphate \>5.5 mg/dL within past 3 months
Intestinal disease that alters absorption or normal intestinal function including celiac disease, small bowel resection, bariatric surgery, or chronic diarrhea/malabsorption
Serious, uncontrolled underlying systemic disease including diabetes, lupus, hypertension in the opinion of their physician
Pregnant or breastfeeding
Prescribed and taken a phosphate binder medication, calcitriol, vitamin D analogs, calcimimetics, PTH analogues, and other medications that may alter Ca and P metabolism within past 4 weeks
Non-English speaking
  • Phosphorus Balance5 days

    Determined by analysis of phosphorus content in complete 24-hour urine and stool collections, subtracted from the diet phosphorus content consumed

  • Calcium Balance5 days

    Determined by analysis of calcium content in complete 24-hour urine and stool collections, subtracted from the diet calcium content consumed