Feasibility Study of Personalized Ultra-fractionated Stereotactic Ablative Radiotherapy (PULSAR) for Central Lung Cancers
This study is testing a new way to deliver radiation therapy called Personalized Ultra-fractionated Stereotactic Ablative Radiotherapy (PULSAR) for cancers in the central part of the lung. This treatment uses a special MRI-guided machine to deliver radiation more precisely, aiming to improve safety while keeping it effective. Researchers want to see if this approach, which involves 5 radiation treatments given every three weeks, can improve how well tumors are seen and reduce side effects. You might be able to join if you are at least 18 years old and have a confirmed cancer diagnosis with a lung tumor that meets specific size and location requirements. The study will look at how long participants survive and how their tumors respond over 4 years. The current status of this study is unclear, and it plans to enroll 30 participants.
- Study design
- This is a single-arm feasibility study, meaning all 30 participants will receive the same treatment. It is not specified if it is blinded.
- What's involved
- You would receive 5 radiation treatments, with one treatment given every 3 weeks. The study does not specify other visits, procedures, or tests.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for survivability and response for 4 years after treatment.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Feasibility Study of Personalized Ultra-fractionated Stereotactic Ablative Radiotherapy (PULSAR) for Cancers of the Central Lung
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- KENNETH WESTOVER, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Texas Southwestern Medical Center
Who to contact
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Do you actually qualify for this trial?
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Inclusion
What this trial measures
- Efficacy- Survivability and response4 years
Rates of overall response will be assessed by RECIST criteria.Efficacy will be compared between PULSAR and historical controls from HILUS using ANOVA and chi-square test. Kaplan-Meier methods will be used to estimate progression-free survival, time to subsequent SABR, overall survival, clinical benefit rate, time to treatment discontinuation, duration of response, and time to new metastases. Response duration will be summarized for patients who responded. Descriptive summary statistics such as median and interquartile range (25% and 75% percentiles) will be used.