Feasibility Study of Personalized Ultra-fractionated Stereotactic Ablative Radiotherapy (PULSAR) for Central Lung Cancers

This study is testing a new way to deliver radiation therapy called Personalized Ultra-fractionated Stereotactic Ablative Radiotherapy (PULSAR) for cancers in the central part of the lung. This treatment uses a special MRI-guided machine to deliver radiation more precisely, aiming to improve safety while keeping it effective. Researchers want to see if this approach, which involves 5 radiation treatments given every three weeks, can improve how well tumors are seen and reduce side effects. You might be able to join if you are at least 18 years old and have a confirmed cancer diagnosis with a lung tumor that meets specific size and location requirements. The study will look at how long participants survive and how their tumors respond over 4 years. The current status of this study is unclear, and it plans to enroll 30 participants.

Study design
This is a single-arm feasibility study, meaning all 30 participants will receive the same treatment. It is not specified if it is blinded.
What's involved
You would receive 5 radiation treatments, with one treatment given every 3 weeks. The study does not specify other visits, procedures, or tests.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for survivability and response for 4 years after treatment.

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NCT06712745

Feasibility Study of Personalized Ultra-fractionated Stereotactic Ablative Radiotherapy (PULSAR) for Cancers of the Central Lung

Recruiting
EARLY_PHASE1Ages 18+InterventionalTreatment
University of Texas Southwestern Medical Center
~30 participants
Updated 2026-06-29 on ClinicalTrials.gov
What's tested:Personalized Ultra-fractionated stereotactic ablative radiotherapy (PULSAR)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Efficacy- Survivability and response
Measured over 4 years
Cancer, Lung
Metastasis
1 sites across 1 states
Texas1
  • KENNETH WESTOVER, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Texas Southwestern Medical Center

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Eligibility criteria

Inclusion

Has not undergone a hysterectomy or bilateral oophorectomy; or
Has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months).
  • Efficacy- Survivability and response4 years

    Rates of overall response will be assessed by RECIST criteria.Efficacy will be compared between PULSAR and historical controls from HILUS using ANOVA and chi-square test. Kaplan-Meier methods will be used to estimate progression-free survival, time to subsequent SABR, overall survival, clinical benefit rate, time to treatment discontinuation, duration of response, and time to new metastases. Response duration will be summarized for patients who responded. Descriptive summary statistics such as median and interquartile range (25% and 75% percentiles) will be used.