Augmented Pacing for Shock in the Cardiac Intensive Care Unit

This study is looking at whether increasing the backup pacing rate in people with a permanent pacemaker and cardiogenic shock (a severe form of heart failure where the heart can't pump enough blood) can improve how well their heart is working. You might be able to join if you are an adult, already in the Cardiovascular Intensive Care Unit (CVICU), have a permanent pacemaker, and are experiencing cardiogenic shock with a slow heart rate. The study will compare a backup pacing rate of 75 beats per minute to 100 beats per minute. Researchers will measure your cardiac index (how much blood your heart pumps per minute) to see if the higher rate helps your heart function better. The study aims to enroll 25 participants.

Study design: This is an interventional study involving 25 participants. You will be exposed to two different pacemaker settings in a random order.
What's involved: Your pacemaker will be programmed to two different backup rates (75 bpm and 100 bpm). Your heart's function will be assessed at baseline and 10 minutes after each rate change.
Compensation: Not stated in the trial record.
Follow-up: Your heart's function will be assessed at baseline and 10 minutes after each rate change, for a total of 30 minutes.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Augmented Pacing for Shock in the Cardiac Intensive Care Unit

Active, Not Recruiting

NAAges 18+InterventionalTreatment

Vanderbilt University Medical Center

~25 participants

Updated 2026-05-06 on ClinicalTrials.gov

What's tested:Backup Pacing Rate Change

At a glance

Recruiting sites

0 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Cardiac Index by thermodilution

Measured over At baseline and 10 minutes after each rate programmed (i.e at 0, 15, and 30 minutes)

Conditions

Cardiogenic Shock

Bradycardia

Shock

Where it's being run

1 sites across 1 states

Tennessee1

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Adults (age 18 and older)

Located in the CVICU

FDA approved permanent pacemaker in place (inclusive of dual-chamber and Bi-Ventricular ICDs) with labeling that allows backup pacing setting at 100 bpm.

Receiving a vasopressor or Inotrope for at least 4 hours

Average HR ≤ 75 bpm over the last hour (on Telemetry review)

Pulmonary artery catheter in place with functioning thermistor and pulmonary artery port.

Exclusion

Single chamber Implantable Cardiac Defibrillator

Sinus rhythm with a leadless pacemaker

Ventricular Tachycardia or Ventricular Fibrillation arrest in last 48 hours

Hemodynamic instability within the last 4 hours, defined as an increase in the dose of norepinephrine \> 10 mcg/min, an increase of epinephrine \> 10 mcg/kg/min, or initiation of a second vasopressor

Alternative indication for pacing rate change (i.e Torsade de Pointes, Recurrent Ventricular Tachycardia)

Comfort-focused care or anticipated death within 24 hours

Mechanical circulatory support in place

Newly discovered pacing system malfunction (lead displacement, loss of capture, elevated capture threshold, significant lead impedance change, battery depletion, undersensing or oversensing)

Non-English Speaking

What this trial measures

Cardiac Index by thermodilutionAt baseline and 10 minutes after each rate programmed (i.e at 0, 15, and 30 minutes)
Cardiac Index measured by thermodilution (in liters per minute per meters squared)

Trialytics