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Observational Study of Lung Cancer Screening in People With Unexplained Weight Loss

This study is looking at whether people who have unexplained weight loss and get screened for lung cancer are more likely to have or develop lung cancer. You might be able to join if you are 50-80 years old, have a history of smoking for at least 20 years, and have had unexplained weight loss (3-10% of your body weight) in the past 18 months. The study involves Low Dose CT imaging (a special X-ray to see inside your lungs) and blood draws. Researchers will also analyze blood samples to see if blood tests can help diagnose lung cancer. The main goal is to see how many participants develop lung cancer over two years. The current status of this study is unclear.

Study design
This is an observational study, meaning researchers will watch and collect information without giving a specific treatment. It plans to include 409 participants.
What's involved
You would have Low Dose CT imaging, blood draws, and complete a screening questionnaire at the beginning of the study and again one year later.
Compensation
Not stated in the trial record.
Follow-up
The study will track the incidence of lung cancer in participants for two years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06717334

A Study of Lung Cancer Screening in People With Unexplained Weight Loss

Recruiting
Not specifiedAges 50–80Observational
Memorial Sloan Kettering Cancer Center
~409 participants
Updated 2026-01-23 on ClinicalTrials.gov
What's tested:Low Dose CT imagingblood drawsscreening questionnaire

At a glance

Recruiting sites
8 of 8 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
The incidence of lung cancer in patients with unexplained weight loss
Measured over 2 years

Conditions

Lung Cancer Screening

Explore related trials

Lung Carcinoma

Where it's being run

8 sites across 2 states
New York5
New Jersey3

Study leadership

  • Puneeth Iyengar, MD, PhD · PRINCIPAL_INVESTIGATOR · Memorial Sloan Kettering Cancer Center

Who to contact

Puneeth Iyengar, MD, PhD
[email protected]
212-639-5159
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Eligible for American Cancer Society lung cancer screening, as follows:
Age 50-80 years old
At least 20-pack year history of smoking
Weight loss of 3-10%, defined as UWL, within any timeframe over the past in the 18 months prior to enrollment, that cannot be attributed to an underlying medical condition at the discretion of the enrolling investigator
Note that patients who have 3-10% weight may still be enrolled if the enrolling investigator does not conclude that the weight loss can be attributed to the patient's intentional efforts.
Documented weight loss can be self-reported or extracted from weights obtained during physician visits. However, if self-reported weight loss is contradicted by weight loss documented in the medical record (e.g. a patients states that (s)he lost 10 lbs in the past 6 months, but a weight documented in the medical record does not support that history), the measured and quantified weight change will be used to ascertain eligibility
Life expectancy greater than 1 year, per assessment of the treating clinician.

Exclusion

Currently pregnant or trying to become pregnant via self-report
Prior history of recent CT scan of the chest either through LDCT screening or with a scan of the chest (standard, not LDCT) performed within the past 12 months
Prior history of NSCLC
Currently undergoing or referred for diagnostic evaluation due to clinical suspicion for malignancy (e.g., referred to a medical or surgical oncologist, or scheduled for biopsy on the basis of a suspicious imaging abnormality).
Patients with a germline pathogenic genetic variant who have undergone whole body MRI within the past 12 months
Unable to comply with study procedures

What this trial measures

  • The incidence of lung cancer in patients with unexplained weight loss2 years

    Low Dose CT screening