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METRICS: Metabolism Evaluation in Bladder Cancer

This observational study, called METRICS, is looking at how your body's energy needs (Resting Energy Expenditure or REE) change during bladder cancer treatment. Researchers want to understand why patients with bladder cancer often experience a decline in physical strength. By monitoring these changes, they hope to find better ways to support patients and improve future care. You may be able to join if you have a confirmed bladder cancer diagnosis, are scheduled for platinum-based chemotherapy followed by surgery (radical cystectomy), and have good kidney and heart function. The study will measure your energy needs from when you enroll until three weeks after your surgery. This information could help doctors detect and treat muscle wasting (cachexia) earlier.

Study design
This is an observational study with a planned enrollment of 30 participants. It is not a treatment study but aims to understand changes in energy needs.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your Resting Energy Expenditure will be measured from enrollment until 3 weeks after radical cystectomy.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06721260

Metabolism Evaluation Through Resting Indirect Calorimetry in Bladder Cancer (METRICS)

Recruiting
Not specifiedAges 18+Observational
University of Kansas Medical Center
~30 participants
Updated 2026-03-20 on ClinicalTrials.gov

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
To assess Resting Energy Expenditure (REE) changes across key treatment milestones.
Measured over From enrollment, prior to chemotherapy, to 3 weeks after radical cystectomy.

Conditions

Bladder Cancer

Explore related trials

Bladder Carcinoma

NCT06721260

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Kansas Medical Center

    Kansas City, Kansasstudy coordinator listed

    Recruiting

  • University of Kansas Medical Center

    Kansas City, Kansasno site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Jill M Hamilton-Reeves, PhD, RD, CSO · PRINCIPAL_INVESTIGATOR · University of Kansas Medical Center

Who to contact

Jill M. Hamilton-Reeves, PhD, RD, CSO
[email protected]
913-588-7650
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Confirmed cancer diagnosis
Scheduled for platinum-based chemotherapy followed by radical cystectomy
Adequate renal and cardiac function for platinum-based chemotherapy

Exclusion

Prior chemotherapy or radiotherapy for bladder cancer
Severe cardiac, renal, hepatic, respiratory or metabolic diseases
Pregnant or breastfeeding
Uncontrolled conditions that could affect study outcomes

What this trial measures

  • To assess Resting Energy Expenditure (REE) changes across key treatment milestones.From enrollment, prior to chemotherapy, to 3 weeks after radical cystectomy.

    Resting Energy Expenditure (REE) will be measured using indirect calorimetry before and after chemotherapy and radical cystectomy and will be associated with clinical outcomes.