Remote Physical Activity for Cancer Survivors with Chemotherapy Side Effects
This study is exploring if a remote physical activity program can help improve outcomes for cancer survivors who have experienced chemotherapy side effects, including cognitive difficulties (often called 'chemo-brain'). You would participate in a 12-week program of aerobic and muscle-strengthening exercises delivered through smartphone apps. Researchers will measure changes in your brain's blood flow (Middle Cerebral Artery Velocity, Cerebrovascular Resistance, and Cerebrovascular Conductance) to see if the program is effective. This study is looking for about 38 participants who are at least 18 years old, can speak English, and had chemotherapy for a non-brain cancer within the last three years, along with self-reported cognitive difficulties. The current status of this study is unclear.
- Study design
- This is an interventional study with an unclear status, planning to enroll 38 participants.
- What's involved
- You would engage in a 12-week remote physical activity program using two smartphone applications.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your brain's blood flow will be measured at the beginning of the study and again after 12 weeks.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Remote Physical Activity Programming to Improve Outcomes in Cancer Survivors With and Without Type 2 Diabetes
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Zachary C Pope, PhD · PRINCIPAL_INVESTIGATOR · University of Oklahoma Health Sciences
- Mikhail Kellawan, PhD · PRINCIPAL_INVESTIGATOR · University of Oklahoma, Department of Health and Exercise Science
- Andriy Yabluchanskiy, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Oklahoma Health Sciences
Who to contact
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What this trial measures
- Middle Cerebral Artery VelocityBaseline and After Study Week 12
We will complete transcranial doppler assessments to measure middle cerebral artery velocity at rest and during exercise.
- Cerebrovascular ResistanceBaseline and After Study Week 12
We will complete transcranial doppler assessments to measure cerebrovascular resistance at rest and during exercise.
- Cerebrovascular ConductanceBaseline and After Study Week 12
We will complete transcranial doppler assessments to measure cerebrovascular conductance at rest and during exercise.
- Cerebrovascular PulsatilityBaseline and After Study Week 12
We will complete transcranial doppler assessments to measure cerebrovascular pulsatility at rest and during exercise.
- Dynamic Cerebral AutoregulationBaseline and After Study Week 12
We will assess dynamic cerebral autoregulation using the Thigh Cuff Release Challenge technique. Large bilateral blood pressure thigh cuffs are rapidly inflated (rapid cuff inflation/deflation system) to occlude the lower limbs. Blood flow will be monitored in the dorsalis pedis artery, and the initial thigh cuff pressure will start at 20 mmHg above systolic blood pressure. If blood flow is still detected, thigh cuff pressure will increase gradually until occlusion is confirmed. The occlusion will be held for 2 min. After 2 min of occlusion, the cuff pressure is rapidly deflated.
- Cognitive FunctionBaseline and After Study Week 12
We will assess cognitive function using the NIH Toolbox-a platform for low-burden, standardized delivery of cognitive function testing. We will employ the NIH Toolbox Cognitive Battery to obtain a Fluid Composite score from all or some of the following five tests: 1) Dimensional Change Card Sort \[executive function\]; 2) Pattern Comparison Processing Speed; 3) List Sorting Working Memory; 4) Flanker Inhibitory Control and Attention; and/or 5) Picture Sequencing Memory. We will score tests per established standards used in other studies employing NIH Toolbox.