PILP for Adult Dentin Caries

This study is looking into a new treatment called Polymer-Induced Liquid Precursor (PILP) for adults with cavities (dentin caries). Researchers want to see if PILP, either as a conditioner or a cement liner, can safely treat cavities in teeth. You might be able to join if you are between 18 and 64 years old, in good general health, and have at least one back tooth with a cavity that reaches the dentin (the layer beneath the enamel). Participants will have PILP or a placebo (an inactive substance) applied to their tooth before a filling. The main goal is to check the safety of PILP and see if it causes any problems for your tooth or overall health.

Study design
This is an interventional study with 30 planned participants, comparing PILP to a placebo. Participants will be randomly assigned to one of three intervention groups.
What's involved
You will have PILP or a placebo applied to your tooth, complete two telephone calls within three months, and visit the clinic at three and six months after your filling. Follow-up evaluations also occur at 48 hours and 1 month post-procedure.
Compensation
Not stated in the trial record.
Follow-up
You will be followed for six months after the dental procedure to monitor for any symptoms or adverse outcomes.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06727110

Polymer Induced Liquid Precursor (PILP) in Adults in With Dentin Caries

Recruiting
NAAges 18–64InterventionalTreatment
University of California, San Francisco
~30 participants
Updated 2026-03-06 on ClinicalTrials.gov
What's tested:PILP CementPILP Conditioner

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pulpal response
Measured over Tooth vitality testing will occur approximatley 3 months and 6 months after placement of the restoration.
Dental Caries
1 sites across 1 states
California1
  • Stefan Habelitz, PhD · PRINCIPAL_INVESTIGATOR · Stefan Habelitz, PhD

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  • Pulpal responseTooth vitality testing will occur approximatley 3 months and 6 months after placement of the restoration.

    Tooth vitality (pulpal response) after intervention.