This observational study, called "Young at Heart," aims to understand how youth-onset type 2 diabetes affects heart and blood vessel (vascular) health in young people. Researchers want to identify factors that might lead to heart disease in individuals aged 12 to 25. They will compare young people with type 2 diabetes to those who are overweight but don't have diabetes, and to healthy individuals of the same age. The study will look at measures like pulse wave velocity (how fast blood travels through arteries) and augmentation index (a measure of arterial stiffness) at the beginning of the study and again after 5 years. Biological parents of participants will also be included for a single visit to help understand family factors.

Study design

This is an observational study with a planned enrollment of 930 participants. It compares three groups of young people: those with type 2 diabetes, those who are overweight, and healthy individuals.

What's involved

Young participants will visit the NIH clinic once a year for up to 25 years, with each visit lasting 4 days. Biological parents will have a single-day visit.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed for at least 5 years, with some measures taken at baseline and again at 5 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.