Cruciferous Vegetable Eating Program for Bladder Cancer

This study is testing a healthy eating program called POW-R Health to see if it can help reduce the chance of bladder cancer coming back (recurrence) or getting worse (progression) in people with early-stage bladder cancer. Researchers want to understand how eating more cruciferous vegetables, like broccoli or cauliflower, might help. You would participate in a behavioral dietary intervention, which involves learning how to increase your intake of these vegetables. The study will compare two versions of the POW-R Health program to see which is more effective. Success will be measured by changes in your urinary isothiocyanates (ITCs) levels, which are chemicals found after eating cruciferous vegetables. This study is for English-speaking adults aged 18 and older who live in New York State and have been diagnosed with certain types of early-stage bladder cancer.

Study design
This is an interventional study with a planned enrollment of 344 participants. It uses a 2-group randomized controlled trial (RCT) design.
What's involved
You would participate in a behavioral dietary intervention called POW-R Health Only/Core or POW-R Health + Maintenance. You would also receive live phone calls as part of a telephone-based intervention.
Compensation
Not stated in the trial record.
Follow-up
Your urinary isothiocyanates (ITCs) levels will be measured at baseline and throughout the study, for up to 24 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06733363

A Cruciferous Vegetable Eating Program for the Reduction of Cancer Recurrence and Progression in Patients With Non-muscle Invasive Bladder Cancer

Recruiting
PHASE2Ages 18+InterventionalPrevention
Roswell Park Cancer Institute
~344 participants
Updated 2026-09-17 on ClinicalTrials.gov
What's tested:Behavioral Dietary InterventionTelephone- Based Intervention

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Urinary isothiocyanates (ITCs) levels
Measured over Baseline throughout life of study - up to 24 months
Non-Muscle Invasive Bladder Carcinoma
Recurrent Bladder Carcinoma
Recurrent Non-Muscle Invasive Bladder Carcinoma
Stage 0a Bladder Cancer AJCC v8
Stage 1 Bladder Cancer AJCC v8

NCT06733363

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Roswell Park Comprehensive Cancer Center

    Buffalo, New Yorkstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Karen Yeary, MD · PRINCIPAL_INVESTIGATOR · Roswell Park Comprehensive Cancer Center

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Eligibility criteria

Inclusion

English speaking
Diagnosed with stage Tis, Ta, or T1 bladder cancer
Age 18 years old or older (no upper limit)
Resides in New York State
Cancer not reported by a lab, nursing home, or death certificate/autopsy only
Did not receive a partial or radical cystectomy
Does not have other cancer diagnosis within 12 month of bladder cancer diagnosis except for cancers deemed low risk and unlikely to impact study participation (e.g., basal cell carcinoma, nor under active treatment for any other cancers

Exclusion

Participants who had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier
Adults unable to consent
Adults unable to complete study measures in English
Individuals who are not yet adults (infants, children, teenagers)
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
Unwilling or unable to follow protocol requirements
The following special populations ae excluded from this study:
Cognitively impaired adults/adults with impaired decision-making capacity
Individuals who are not yet adults (infants, children, teenagers)
Pregnant women
Prisoners
  • Urinary isothiocyanates (ITCs) levelsBaseline throughout life of study - up to 24 months

    Levels with be measured using high performance liquid chromatography-based cyclocondensation assay