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Evaluating Evidence-Based Options for PTSD Treatment

This study is looking at how well different proven therapies work for people with Post-Traumatic Stress Disorder (PTSD) who haven't responded to their first treatment. The therapies being studied are Cognitive Processing Therapy, Prolonged Exposure, and Skills Training for Affective and Interpersonal Regulation (STAIR). Researchers want to see how practical it is to offer these therapies again and how effective they are. The goal is to improve personalized care by finding out what predicts how someone will respond to a second treatment and to create a tool to help identify early on who might need a different approach. You may be able to join if you are 18 or older, fluent in English, have experienced a traumatic event, and have a confirmed PTSD diagnosis. Success will be measured by changes in your PTSD symptoms, as reported by you and a clinician, over a 6-month period. The current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 400 participants. It will compare different behavioral therapies for PTSD.
What's involved
You would need to attend 10 therapy sessions over 2 weeks (10 days), and possibly more sessions later.
Compensation
Not stated in the trial record.
Follow-up
Your PTSD symptoms will be monitored from the start of the study up to 6 months after treatment.

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NCT06733376

Evaluating Evidenced Based Options for PTSD Treatment

Recruiting
NAAges 18+InterventionalTreatment
Rush University Medical Center
~400 participants
Updated 2025-10-22 on ClinicalTrials.gov
What's tested:Cognitive Processing TherapyProlonged ExposureSkills Training for Affective and Interpersonal Regulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
PTSD Checklist for DSM-5 (PCL-5)
Measured over Baseline to 6 month follow up
+1 more outcome measured

Conditions

PTSD - Post Traumatic Stress Disorder

Explore related trials

Post-Traumatic Stress Disorder

Where it's being run

1 sites across 1 states
Illinois1

Who to contact

Philip Held, PhD
[email protected]
312-942-1423
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Are 18 years or older
Are fluent in English
Have experienced a Criterion A traumatic event during their lifetime
Have a PTSD diagnosis verified via the Clinician Administered PTSD Scale for DSM-5
Are interested in receiving evidence-based treatment for PTSD and able to attend 10 therapy sessions over the course of 2 weeks (10 days) and could possibly attend another 10 sessions of a subsequent treatment (additional CPT sessions, PE, or STAIR)
Are willing and able to complete self-report measures and clinician-rated assessments at multiple timepoints over the course of the study

Exclusion

The index traumatic event occurred in the past month
They are currently suicidal or homicidal (i.e., current plan and imminent intent)
They have unmanaged psychosis or mania
They have not been on a stable dose of psychotropic medication for at least one month at the time of the baseline assessment
They have completed an evidence-based cognitive behavioral PTSD treatment in the past three months or are currently engaged in an evidence-based PTSD treatment (CPT, PE)
They have an intellectual disability or significant cognitive impairment that would prevent them from engaging in treatment
They have a serious or unstable medical illness or instability for which hospitalization may be likely within the next year
They have an active substance use disorder (within the past three months) that would require immediate medical observation if substance was abruptly discontinued
They are involved with current legal actions related to their index trauma
They have a visual or auditory impairment that would prevent them from fully participating in study activities
They, at the time of consent, appear to have extenuating life circumstances (i.e., unstable housing, no internet access, etc.) which, in the judgement of the study team, could affect the ability to deliver interventions with fidelity

What this trial measures

  • PTSD Checklist for DSM-5 (PCL-5)Baseline to 6 month follow up

    A self-report measure of PTSD symptom severity

  • Clinician Administered PTSD Scale for DSM-5Baseline to 6 mont follow up

    A clinician-rated assessment of PTSD