Working Memory Training for Mild Cognitive Impairment
This study is testing if a special computer program called CogMed can help improve memory in people with mild cognitive impairment (MCI), which is an early stage of memory problems. Researchers also want to see if CogMed can help reduce stress. They are looking for about 10 participants aged 50 or older who meet the Mayo Clinic criteria for MCI and have internet access. You also need to be able to speak and read English, or have a family member who can translate. The study will measure changes in your working memory and stress levels at the beginning and again three months after the training. They are also exploring if CogMed affects a blood marker related to Alzheimer's disease, called p-Tau 217.
- Study design
- This is an interventional study comparing CogMed training plus usual care to usual care alone, with a planned enrollment of 10 participants.
- What's involved
- You would participate in the CogMed training program and have your working memory and stress levels assessed at the start and again three months later. Blood draws for p-Tau 217 levels are also part of the study.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your working memory will be assessed at a 3-month follow-up after the intervention period.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Working Memory Training in Patients with Mild Cognitive Impairment
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Yonas E Geda, M.D, MSc · PRINCIPAL_INVESTIGATOR · Barrow Neurological Institute, Alzheimer's Disease and Cognitive Disorders Division
Who to contact
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What this trial measures
- Working Memory as measured by the WAIS-IV Digit Span Forward/BackwardWill be assessed at baseline and again at a 3-month follow-up following the intervention period.
The Digit Span Forward/Backward is a subset of the Wechsler Adult Intelligence Scale (WAIS) that captures attention efficiency and working memory.
- Working Memory as measured by the TMT-BWill be assessed at baseline and again at a 3-month follow-up following the intervention period.
The Trail Making Test (TMT) is a well-established test sensitive to impairment in multiple cognitive domains.
- Working Memory as measured by Category Fluency TestWill be assessed at baseline and again at a 3-month follow-up following the intervention period.
The Category Fluency Test (CFT) was created to assess semantic fluency. It consists of asking the individual to name as many animals as possible in 60 s. Performance on CFT can be evaluated through several components, such as the number of correct words, clusters, switching, related words, and intrusion and perseveration errors.