Folic Acid Salt Study (FISFA Zambia)

This study, called FISFA Zambia, is looking at how well iodized salt fortified with folic acid (FISFA) can increase folate levels in women in Zambia. Folate deficiency can lead to neural tube defects (serious birth defects of the brain and spine). Researchers want to see if adding folic acid to salt, which people use daily, can help prevent these defects. You might be able to join if you are a woman between 18 and 45 years old, not pregnant or breastfeeding, and do not plan to get pregnant. The study will measure changes in your blood folate levels over six months to see if the fortified salt is effective. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 250 women. It is a nonrandomized controlled intervention trial.
What's involved
You would consume salt with folic acid for six months instead of your usual salt. You would also have blood drawn four times and fill out surveys.
Compensation
Not stated in the trial record.
Follow-up
Your folate levels will be measured at baseline, month 1, month 3, and month 6 (the endpoint).

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NCT06734611

Folic Acid Salt Study (FISFA Zambia)

Recruiting
NAAges 18–45InterventionalPrevention
University of Alabama at Birmingham
~250 participants
Updated 2026-06-29 on ClinicalTrials.gov
What's tested:Fortified Iodized Salt with Folic Acid (FISFA)

At a glance

Recruiting sites
1 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Measure change in median and mean serum folate levels between baseline, month 1, month 3 and month 6 (endpoint)
Measured over 0-6 months
+1 more outcome measured
Folate Deficiency
Neural Tube Defects
2 sites across 2 states
Alabama1
Zambia1
  • Anastasia A Smith, DrPH · PRINCIPAL_INVESTIGATOR · University of Alabama at Birmingham

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Eligibility criteria

Inclusion

Voluntary participation in the study
Do not intend to get pregnant
Not lactating or pregnant
Live alone or with a partner if they can be compliant and not share the study salt.
Aged between 18 and 45 years

Exclusion

Pregnant or lactating
  • Measure change in median and mean serum folate levels between baseline, month 1, month 3 and month 6 (endpoint)0-6 months

    Evaluate folate blood levels pre and post intervention

  • Measure change in median and mean red blood cell folate levels between baseline, month 1, month 3 and month 6 (endpoint)0-6 months

    Evaluate folate blood levels pre and post intervention