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Ketogenic Diets for Weight Loss Maintenance in Individuals with Obesity

This study is looking at how different diets affect weight loss maintenance in people with obesity. It aims to see if a ketogenic diet (a very low-carb diet) can help your body burn more energy and manage appetite better after you've lost weight. You would first follow a low-calorie diet for 4 weeks to lose at least 5% of your body weight. Then, you would be randomly assigned to either a ketogenic diet or a standard low-fat diet for 6 weeks, with food provided. The study will measure changes in how much energy your body uses. This study is for adults aged 18-65 with a BMI between 30-45 kg/m2. The study is currently recruiting about 20 participants.

Study design
This is an interventional study that will enroll about 20 participants. After an initial weight loss phase, participants will be randomly assigned to one of two diet groups.
What's involved
You would participate in the study for a total of 10 weeks. This includes 4 weeks on a low-energy diet, followed by 6 weeks on either a ketogenic or low-fat diet. You would also meet weekly with a registered dietitian.
Compensation
Not stated in the trial record.
Follow-up
Your total energy expenditure will be measured at the beginning of the study, at week 6, and at week 10.

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NCT06736028

Ketogenic Diets for Weight Loss Maintenance: Impact on Energy Expenditure and Appetite in Individuals With Obesity

Recruiting
NAAges 18–65InterventionalTreatment
University of Alabama at Birmingham
~20 participants
Updated 2026-04-07 on ClinicalTrials.gov
What's tested:Diet TherapyCalorie RestrictionBehavioral Support

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change from baseline total energy expenditure
Measured over Baseline, week 6, week 10

Conditions

Obesity

Explore related trials

Obesity

Where it's being run

1 sites across 1 states
Alabama1

Who to contact

Catia Martins, PhD
[email protected]
205-934-7922
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

BMI 30-45 kg/m2
Both men and women
Age between 18-65 years
Sedentary to moderately active (\<2 h/wk of moderate, structured, intentional, exercise)

Exclusion

Pregnancy or lactation
Daily use of tobacco (\>1 pk/wk)
Change in weight greater than 5 lb in the previous 3 months
Cognitive impairment
Previous bariatric surgery
History of eating disorder
Presence of any condition (e.g. DM2, PCOS, inflammatory disease, untreated thyroid disease, fluid overload states such as chronic kidney disease, congestive heart failure, or cirrhosis)
Use of any medication (e.g., glucocorticoid, GLP-1 analogues, hormone replacement therapy) deemed to interfere with study outcomes.
Pre-menopausal women will need to have a regular menstrual cycle (28+/-2 days) or be on hormonal contraceptives
Fasting glucose plasma concentration \>125 mg/dl and/or HbA1c \> 6.4%

What this trial measures

  • Change from baseline total energy expenditureBaseline, week 6, week 10

    Total Energy Expenditure (TEE) refers to the total amount of energy (calories) your body uses in a day. Twenty-four-hour EE and RQ will be measured inside the whole room indirect calorimeter (chamber) following standard procedures