Observational Study on Preeclampsia and Heart Health
This observational study is looking into the connection between preeclampsia (a serious pregnancy complication involving high blood pressure) and future heart health. Researchers want to understand if preeclampsia acts like a "failed stress test" for your heart, potentially leading to heart problems later on, specifically a condition called heart failure with preserved ejection fraction (HFpEF). They will compare 250 women who had preeclampsia with 250 women who had normal blood pressure during pregnancy. The main goal is to see if there's a link between preeclampsia and early signs of heart muscle weakness (subclinical LV diastolic dysfunction) one year after giving birth, using ultrasound images of the heart (echocardiography). You might be eligible if you are a woman over 18 who gives birth at VUMC and has a diagnosis of preeclampsia.
- Study design
- This is an observational study aiming to enroll 500 women (250 with preeclampsia and 250 without) to compare heart health outcomes.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 12 months after giving birth to measure heart function.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Exercise Testing After Preeclampsia
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Kathryn Lindley, MD, FACC · PRINCIPAL_INVESTIGATOR · VUMC
Who to contact
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What this trial measures
- To measure relation between postpartum subclinical LV diastolic dysfunction and pregnancy-specific risk factors in 250 women with PreE and 250 normotensive women through echocardiographic imaging.12 months
Pre-pregnancy risk factors (HTN, DM, delivery body mass index \[BMI\], age), pregnancy-specific risk factors (PreE severity, gestational age at delivery, gravidity, GDM, SGA) and PP risk factors (weight change, median systolic BP 0-2 weeks PP, resting BP at study visit) will be measured. Ordinary least squares (OLS) regressions will be used to estimate the relationship between Lateral E/e' at 52 weeks and the above risk factors, adjusting for baseline values, to determine if the diastolic function parameters are affected by the risk factors of interest.