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The INSPIRE-Faith Study: Lifestyle Interventions for Cognitive Health

The INSPIRE-Faith Study is looking at how lifestyle changes can help maintain brain health and prevent dementia. This study will compare a Lifestyle Intervention, which includes health coaching, diet changes, and exercise, with Standard Health Education materials. We are looking for 2,000 participants, aged 55 to 85, who have normal thinking abilities, mild cognitive impairment (MCI), or subjective cognitive impairment (SCI). The main goal is to see if the Lifestyle Intervention improves cognitive function (thinking and memory) over 6 months, 1 year, and 3 years. This study is focused on communities affected by lifestyle-dependent diseases, starting in South Los Angeles.

Study design
This is an interventional study with 2,000 participants. Participants will be randomly assigned to one of two groups.
What's involved
Participants will undergo an initial assessment of medical history, cognitive function, and lifestyle. Those in the intervention group will receive personalized guidance, participate in an online community, and access exercise programs and educational materials.
Compensation
Not stated in the trial record.
Follow-up
Participants' cognitive function will be measured at 6 months, 1 year, and 3 years.

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NCT06741865

The INSPIRE -Faith Study: Intervention Strategies for Preserving Intellectual Resilience and Engagement

Recruiting
NAAges 55–85InterventionalPrevention
Healthy Minds Initiative
~2,000 participants
Updated 2026-05-28 on ClinicalTrials.gov
What's tested:Lifestyle InterventionStandard Health Education

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Cognitive Function
Measured over 6 months, 1 year and 3 years

Conditions

Dementia

Explore related trials

Mild cognitive disorderNormal Cognitive StatusSevere Cognitive Impairments

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Dean Sherzai, MD, PhD · PRINCIPAL_INVESTIGATOR · Healthy Minds Initiative

Who to contact

Dean Sherzai, MD, PhD
[email protected]
949-383-6729
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age: Participants must be 55 years of age or older.
Ethnicity: Focused on African American individuals, but not exclusive.
Cognitive Status: Participants must have normal cognitive status, mild cognitive impairment (MCI), or subjective cognitive impairment (SCI).
Language: Participants must be fluent in English.
Location: Must reside in the Crenshaw, California area or\* be able to attend study-related activities in this location. \*online access is available for those not in this area.
Willingness to Participate: Participants must be willing to adhere to the study protocol, including attending assessments, participating in interventions, and completing questionnaires.

Exclusion

Cognitive Decline: Diagnosis of dementia or severe cognitive impairment that would interfere with the ability to participate in the study.
Physical Limitations: Any physical or medical condition that would preclude participation in the lifestyle interventions (e.g., severe mobility issues).
Recent Cancer Diagnosis: Diagnosis of cancer within the last three years, excluding stable cases of basal cell or squamous cell carcinoma of the skin, or stable prostate cancer.
Pregnancy: Current pregnancy or planning to become pregnant during the study period.
Mental Health: Diagnosis of severe psychiatric disorders such as schizophrenia or bipolar disorder that might interfere with participation.
Substance Abuse: Current substance abuse or dependency that could impact participation.
Hearing Impairment: Uncorrected hearing loss that would limit the ability to communicate and participate in the study.
Non-English Speaking: Inability to participate in English-language oral and written cognitive assessments.
Participation in Another Study: Currently enrolled in another clinical trial that could interfere with the INSPIRE Study.
Life expectancy less than 3 years
Unwillingness to share medical and laboratory information.

What this trial measures

  • Change in Cognitive Function6 months, 1 year and 3 years

    Change in global composite score from baseline, as measured by the TABCAT (Tablet-based Cognitive Assessment Tool) composite score, at the designated endpoint (e.g., 6 months, 1 year, and 3 years). This composite score reflects core domains of cognition-including memory, executive function, language, and processing speed-captured through standardized TABCAT assessments.