Decision-Making in Schizophrenia: A Combined Neuroimaging and Experience Sampling Study
This study is looking at how attention and different ways of thinking affect decision-making and brain activity in people with schizophrenia or schizoaffective disorder, compared to people without these conditions. You would identify personal goals and then complete a gambling task while having a functional MRI (fMRI) scan, which measures brain activity. Researchers want to see if specific ways of thinking improve brain processes related to decision-making and how brain activity during decision-making relates to real-world choices. The study aims to enroll 74 participants aged 18 to 50 who can speak English fluently.
- Study design
- This is an interventional study that plans to enroll 74 participants, including those with schizophrenia, schizoaffective disorder, and control subjects.
- What's involved
- You would identify personal goals and then complete a gambling task during a 1.5-hour functional MRI (fMRI) scan and behavioral task.
- Compensation
- Not stated in the trial record.
- Follow-up
- Brain activation and gambling choice behavior are measured at a single timeframe during the 1.5 hours of MRI scanning and behavioral task completion.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Decision-Making in Schizophrenia: A Combined Neuroimaging and Experience Sampling Study
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- David Zald, PhD · PRINCIPAL_INVESTIGATOR · Rutgers University
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Nucleus Accumbens Brain ActivationSingle timeframe during 1.5 hours of MRI scanning and behavioral task completion.
Brain activation in the nucleus accumbens (ventral striatum) measured via functional magnetic resonance imaging (fMRI) on trials that are preceded by the cognitive regulation strategy relative to trials without the cognitive regulation strategy.
- Gambling Choice BehaviorSingle timeframe during 1.5 hours of MRI scanning and behavioral task completion.
Risky reward pursuit, defined as gamble choices on trials that are preceded by the cognitive regulation strategy relative to trials without the cognitive regulation strategy.