Decision-Making in Schizophrenia: A Combined Neuroimaging and Experience Sampling Study

This study is looking at how attention and different ways of thinking affect decision-making and brain activity in people with schizophrenia or schizoaffective disorder, compared to people without these conditions. You would identify personal goals and then complete a gambling task while having a functional MRI (fMRI) scan, which measures brain activity. Researchers want to see if specific ways of thinking improve brain processes related to decision-making and how brain activity during decision-making relates to real-world choices. The study aims to enroll 74 participants aged 18 to 50 who can speak English fluently.

Study design
This is an interventional study that plans to enroll 74 participants, including those with schizophrenia, schizoaffective disorder, and control subjects.
What's involved
You would identify personal goals and then complete a gambling task during a 1.5-hour functional MRI (fMRI) scan and behavioral task.
Compensation
Not stated in the trial record.
Follow-up
Brain activation and gambling choice behavior are measured at a single timeframe during the 1.5 hours of MRI scanning and behavioral task completion.

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NCT06745479

Decision-Making in Schizophrenia: A Combined Neuroimaging and Experience Sampling Study

Recruiting
NAAges 18–50InterventionalBasic science
Rutgers, The State University of New Jersey
~74 participants
Updated 2026-03-11 on ClinicalTrials.gov
What's tested:Positive Emotion Upregulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Nucleus Accumbens Brain Activation
Measured over Single timeframe during 1.5 hours of MRI scanning and behavioral task completion.
+1 more outcome measured
Schizophrenia
Schizoaffective Disorder
Control Subjects
1 sites across 1 states
New Jersey1
  • David Zald, PhD · PRINCIPAL_INVESTIGATOR · Rutgers University

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  • Nucleus Accumbens Brain ActivationSingle timeframe during 1.5 hours of MRI scanning and behavioral task completion.

    Brain activation in the nucleus accumbens (ventral striatum) measured via functional magnetic resonance imaging (fMRI) on trials that are preceded by the cognitive regulation strategy relative to trials without the cognitive regulation strategy.

  • Gambling Choice BehaviorSingle timeframe during 1.5 hours of MRI scanning and behavioral task completion.

    Risky reward pursuit, defined as gamble choices on trials that are preceded by the cognitive regulation strategy relative to trials without the cognitive regulation strategy.