Activity Coaching During Pelvic Radiation Therapy for Endometrial Cancer

This study is looking at whether an activity coaching program can help women with endometrial cancer who are receiving pelvic radiation therapy. Radiation therapy can cause fatigue, making daily activities harder. While exercise is known to help with cancer-related fatigue, its role specifically during pelvic radiation therapy hasn't been studied much. This research will test an Exercise Coaching program, where you'll work with a certified coach to set weekly activity goals. The main goal of this study is to see if it's practical to conduct a larger study on this topic, by looking at how well participants stick with the coaching sessions. The study plans to enroll 16 women who are at least 18 years old, have Stage I-IVA endometrial cancer, have had a hysterectomy, and are scheduled for pelvic external beam radiation therapy.

Study design
This is an interventional study planning to enroll 16 participants. Participants will be placed into either an Immediate Start or Delayed Start Activity Coaching Program.
What's involved
You would participate in ten weekly check-ins with an exercise coach, receive a Fitbit, complete four surveys, and undergo four 6-minute walking tests. You will also participate in an interview at the end of the study.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed from enrollment up to 24 months after the study begins.

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NCT06746428

Activity Coaching During Pelvic Radiation Therapy

Recruiting
NAAges 18+InterventionalTreatment
Inova Health Care Services
~16 participants
Updated 2026-08-03 on ClinicalTrials.gov
What's tested:Exercise Coaching

At a glance

Recruiting sites
4 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Feasibility of a Randomized Trial: Participant Adherence to Exercise Coaching Sessions
Measured over Enrollment to end of follow up, up to 24 months
Radiation Therapy
Gynecologic Cancer
Exercise Therapy
4 sites across 1 states
Virginia4
  • Avani Rao, MD · PRINCIPAL_INVESTIGATOR · Inova Health Care Services

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Eligibility criteria

Inclusion

At least 18 years of age
Pathologic diagnosis of endometrial cancer (any histology, Stage I-IVA)
Has undergone modified radical or radical hysterectomy
Plan to receive adjuvant treatment with pelvic external beam radiation therapy at ISCI
ECOG performance status of 0-1
Patient has a computer, smart phone, or tablet virtual access to the web-based platform and email
Able to read, understand and provide written informed consent
Deemed appropriate for unmonitored exercise by treating physician based on the following evidence-based criteria (1)
Walk without any assistance or assistance device
Absence of significant cognitive impairment
Absence of high risk for falls
Participant does not need to refrain from any activity

Exclusion

Unable to schedule and attend coaching visits
Participation in a regular exercise program of ≥150 minutes of moderate intensity exercise a week at baseline
Unable to perform the five-times stand test
Medical comorbidities including:
Unstable angina
Uncontrolled dysrhythmias
Acute pulmonary embolus
Active pulmonary infection
  • Feasibility of a Randomized Trial: Participant Adherence to Exercise Coaching SessionsEnrollment to end of follow up, up to 24 months

    Participant adherence to coaching sessions will be defined as complete adherence when engaging in 10 of the 10 planned exercise coaching sessions and high adherence as engaging in at least 7 of the planned 10 exercise coach check-ins. Participant adherence will be considered feasible if 70% of participants adhere to the coaching sessions.