Non-Endoscopic Screening for Barrett's Esophagus in Veterans

This study is looking at a new way to screen for Barrett's esophagus (a condition that can lead to esophageal cancer) in veterans. It's for people aged 40 to 85 who don't have ongoing heartburn or reflux but have other risk factors like obesity, tobacco use, or a family history of esophageal cancer. The study will use a non-endoscopic test called Esocheck/Esoguard, which involves swallowing a small balloon device to collect cells. Participants will also have a standard upper endoscopy (a procedure where a thin, flexible tube with a camera is used to look at your esophagus). The main goal is to see if the Esoguard test can accurately identify Barrett's esophagus or esophageal cancer, with results expected within 10 to 30 days.

Study design
This is an interventional study planning to enroll 400 participants. It is not specified if it is randomized or blinded.
What's involved
You would complete the Esocheck/Esoguard test and have a diagnostic upper endoscopy.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, which is the diagnosis of Barrett's esophagus or esophageal adenocarcinoma, will be measured within 10 to 30 days.

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NCT06746623

Nonendoscopic Screening for Barrett's Esophagus in Veterans Without Chronic Reflux

Recruiting
NAAges 40–85InterventionalDiagnostic
Louis Stokes VA Medical Center
~400 participants
Updated 2025-06-05 on ClinicalTrials.gov
What's tested:Enrolled participants will complete Esocheck/Esoguard and diagnostic upper endoscopy.

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Esoguard assay and histology confirming diagnosis of Barrett's esophagus and/or esophageal adenocarcinoma
Measured over Laboratory and pathology results will be finalized within 10 and up to 30 days
Obese Patients
Tobacco Use
Veterans
Family History of Esophageal Cancer
Barrett Esophagus
1 sites across 1 states
Ohio1
  • Katarina B Greer, MD/MS · PRINCIPAL_INVESTIGATOR · Cleveland VA Research and Education Foundation

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Eligibility criteria

Inclusion

Patients without history of chronic GERD who meet criteria for upper endoscopic screening for BE will be accrued35.
  • Esoguard assay and histology confirming diagnosis of Barrett's esophagus and/or esophageal adenocarcinomaLaboratory and pathology results will be finalized within 10 and up to 30 days

    Results from enrollment visit