This study, called ARIADNE, is testing different ways to perform a catheter ablation procedure for people with persistent atrial fibrillation (AF). Catheter ablation is a procedure that uses energy to create small scars in the heart to block faulty electrical signals that cause AF. In this study, doctors will use a special catheter (a thin, flexible tube) that can switch between two types of energy: radiofrequency ablation (RFA) and pulsed field ablation (PFA). You would be randomly assigned to one of three ablation strategies. The main goal is to see how many people are free from AF after 12 months. To join, you must be between 18 and 80 years old, have symptomatic persistent AF, and be a suitable candidate for catheter ablation. The current recruitment status is unclear.

Study design

This is a randomized study with about 60 participants. You would be assigned to one of three different ablation strategies.

What's involved

You would undergo a catheter ablation procedure. An implantable loop recorder will be placed to continuously monitor your heart rhythm.

Compensation

Not stated in the trial record.

Follow-up

Your heart rhythm will be monitored for 12 months after the procedure to see if the treatment was successful.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.