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Behavioral Intervention for Youth to Promote Vaping Cessation

This study is looking for young people aged 14-19 who vape nicotine regularly and want to quit or reduce their vaping. It aims to see if two different behavioral interventions can help them stop vaping. One intervention, called QuitVaping, is a modified program based on the American Lung Association's smoking cessation program, along with text message support. The other intervention, called This is Quitting (TIQ), is a free text message program designed to help teens quit vaping. The study will compare these interventions to standard education and advice. We are looking for about 400 participants. The main goal is to see how many participants can stay nicotine-vaping-free for four continuous weeks at the end of the 12-week treatment period.

Study design
This is an interventional study with approximately 400 participants, randomly assigned to one of two groups. The intervention is double-blind, meaning neither the participants nor the assessors know which treatment group they are in.
What's involved
Participants will have 12 weekly study visits, followed by monthly visits until week 36. Visits can be done remotely via video or in person, and will include assessments and biochemical verification of abstinence.
Compensation
Not stated in the trial record.
Follow-up
Participants will have follow-up visits at weeks 16, 20, 24, 28, 32, and 36 after the 12-week intervention period.

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NCT06765291

Behavioral Intervention for Youth to Promote Vaping Cessation

Recruiting
NAAges 14–19InterventionalTreatment
Massachusetts General Hospital
~400 participants
Updated 2026-07-07 on ClinicalTrials.gov
What's tested:QuitVapingThis is Quitting (TIQ)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Continuous 4-week nicotine vaping abstinence at end of treatment
Measured over From week 9 to week 12

Conditions

Vaping
Vaping Teens
Nicotine Dependence

Explore related trials

Nicotine DependenceVaping Cessation

Where it's being run

1 sites across 1 states
Massachusetts1

Study leadership

  • A. Eden Evins, MD, MPH · PRINCIPAL_INVESTIGATOR · Massachusetts General Hospital
  • Randi M. Schuster, PhD · PRINCIPAL_INVESTIGATOR · Massachusetts General Hospital

Who to contact

A. Eden Evins, MD, MPH
[email protected]
617-643-4679
Email the study team

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Eligibility criteria

Inclusion

Age 14-19 inclusive
Self-report of at least weekly nicotine vaping (or use of other non combusted nicotine products, "vaping") for the prior ≥3 months
Self-report of no regular combusted tobacco use (i.e., 5 or more days of smoke smoked tobacco use per week) prior to enrollment and exhaled CO \<10 ppm for those with an in person baseline visit
Report willingness to try to quit or reduce vaping in the next 30 days
Able to understand study procedures and read and write in English or Spanish
Have a parent or legal guardian who is able to participate in the opt out process
Competent and willing to provide written informed consent (if age 18) or assent (if under 18)

Exclusion

Use of a smoking cessation medication in the prior month (nicotine patch, gum, nasal spray, or inhaler, varenicline, bupropion)
Unwilling to abstain during the study from using smoking cessation aids other than those provided by the study
Unwilling to provide saliva or urine samples
Any condition or situation that would, in the investigator's opinion, make it unlikely that the participant could adhere safely to the study protocol

What this trial measures

  • Continuous 4-week nicotine vaping abstinence at end of treatmentFrom week 9 to week 12

    The percent of participants who self-report nicotine vaping abstinence since the last visit on the timeline followback interview and have cotinine \<10ng/mL, assessed at study weeks 9-12. The primary comparison of interest is between the QV + EUC arms.