Melatonin Lotion for Sleep and Mental Health in Young Adults
This study is testing if a melatonin lotion can help young adults (ages 18-21) who have sleep problems, anxiety, or depression. Melatonin is a natural hormone that helps regulate sleep. You would apply 3 grams of melatonin lotion or a placebo lotion (a lotion without medicine, but with the same scent) to your skin one hour before bedtime. Researchers will measure your sleep disturbance, anxiety, and depression levels to see if the melatonin lotion helps. To join, you need to have specific scores on surveys related to sleep disturbance, anxiety, or depression. You cannot be pregnant or currently using certain medications for sleep, anxiety, or depression, including melatonin. The study aims to enroll 60 participants, but its current status is unclear.
- Study design
- This is an interventional study with 60 planned participants. All participants will receive both melatonin lotion and a placebo lotion in a randomized crossover design, meaning the order in which you receive them is random.
- What's involved
- You will self-apply lotion nightly for two separate weeks, wear a wrist device (actigraph) and a chest strap (heart rate monitor), answer daily mood questions, and collect nightly saliva samples. There will be a seven-day break (washout period) between the two treatment weeks.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your sleep, anxiety, and depression will be measured at the beginning, after the placebo week, and after the active treatment week (3 weeks total).
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
The Impact of Melatonin Lotion on Sleep and Mental Health
At a glance
Conditions
NCT06768749
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Redlands
Redlands, Californiastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Lisa E Olson, Ph.D. · PRINCIPAL_INVESTIGATOR · University of Redlands
Who to contact
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Inclusion
Exclusion
What this trial measures
- Sleep disturbanceMeasured pre-treatment, at end of placebo week, and at end of active treatment week (3 weeks total)
PROMIS SF v1.0 - Sleep Disturb 8b
- AnxietyMeasured pre-treatment, at end of placebo week, and at end of active treatment week (3 weeks total)
PROMIS SF v1.0 - Anxiety 8a
- DepressionMeasured pre-treatment, at end of placebo week, and at end of active treatment week (3 weeks total)
PROMIS SF v1.0 - Depression 8b
- Total sleep timeTwo weeks of data separated by a one week period
Measured via actigraphy
- Sleep efficiencyTwo weeks of data separated by a one week period
Measured by actigraphy
- Normalized high frequency power of heart rate variabilityTwo weeks of data separated by a one week period
5 min period during sleep latency, overnight recording while sleeping, and 5 min period sitting upright each morning
- Anxiety by momentary ecological assessmentThree times per day for two weeks of data separated by a one week period
One item question: "How anxious do you feel right now?"
- Mood by momentary ecological assessmentThree times per day for two weeks of data separated by a one week period
Single-item questions ("How \_\_\_ do you feel right now?)
- Salivary alpha-amylaseDaily at bedtime for two weeks of data separated by a one week period
As an indicator of sympathetic nervous system activity