Lifestyle Interventions for Obesity

This study is testing two different lifestyle programs for people with obesity. One is a Standard Lifestyle Intervention (SLI) program, which gives recommendations for diet, exercise, and behavior changes. The other is a Phenotype-tailored Lifestyle Intervention (PLI) program, which also provides diet, exercise, and behavior recommendations, but these are specifically designed for your individual type of obesity. Both programs last for 12 months and are led by a team of experts. The study aims to see if these programs can help people lose weight and keep it off. You may be able to join if you are between 18 and 65 years old with a BMI over 30 (obesity) and meet other health criteria. The main goal is to measure how much total body weight is lost after 52 weeks. The current recruitment status is unclear.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 228 participants.
What's involved
Participants will follow either the Standard Lifestyle Intervention or Phenotype-tailored Lifestyle Intervention program for 12 months.
Compensation
Not stated in the trial record.
Follow-up
Your total body weight loss will be measured at the beginning of the study and again after 52 weeks.

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NCT06770049

Phenotype-Tailored Lifestyle Intervention for Obesity: A Randomized Trial

Recruiting
NAAges 18–65InterventionalTreatment
Mayo Clinic
~228 participants
Updated 2026-06-11 on ClinicalTrials.gov
What's tested:Standard Lifestyle Intervention (SLI) programPhenotype-tailored Lifestyle Intervention (PLI) program

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Total Body Weight Loss (TBWL)
Measured over Baseline, 52 weeks
Obesity
1 sites across 1 states
Minnesota1
  • Andres Acosta, MD,PhD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

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  • Total Body Weight Loss (TBWL)Baseline, 52 weeks

    Change in Total Body Weight Loss (TBWL) in kg