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Transcranial Magnetic Stimulation (TMS) Effects on Alcohol Use Disorder

This study is looking at how different types of transcranial magnetic stimulation (TMS) affect the brain in people with and without alcohol use disorder (AUD). TMS is a non-invasive way to change brain activity. Researchers want to understand how TMS works on brain circuits involved in AUD. You might receive sham iTBS (inactive TMS), active iTBS, 10 Hz TMS, or 1 Hz TMS. The study is open to adults aged 21 to 65. To join, you either need to have a diagnosis of AUD and be a heavy alcohol consumer, or not have AUD and not be a heavy alcohol consumer. The main goal is to track any side effects from TMS throughout the study, which lasts up to one year. The current status of this study is unclear.

Study design
This interventional study plans to enroll 10 participants. It uses a mixed design, comparing different TMS sequences within individuals and between groups (with and without AUD).
What's involved
You would have several study visits, each on a separate day. Each visit involves a brain scan (MEG), a TMS treatment, and then three more MEG scans over a few hours. You will also have an MRI scan.
Compensation
Not stated in the trial record.
Follow-up
Your safety will be monitored for potential adverse events related to TMS throughout the study, which can last up to one year.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06770556

Transcranial Magnetic Stimulation (TMS) Effects Using Magnetoencephalography (MEG) Study

Completed
NAAges 21–65InterventionalBasic science
Wake Forest University Health Sciences
~5 participants
Updated 2026-08-17 on ClinicalTrials.gov
What's tested:Sham iTBSActive iTBS10 Hz TMS1 Hz TMS

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of Adverse Events Potentially Related to TMS
Measured over Through study completion 1 year

Conditions

Alcohol Use Disorder
Alcohol Dependence
Alcohol Consumption

Explore related trials

Alcohol use disorder

Where it's being run

1 sites across 1 states
North Carolina1

Study leadership

  • Merideth A Addicott, PhD · PRINCIPAL_INVESTIGATOR · Wake Forest University Health Sciences

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Diagnostic and Statistical Manual of Mental Disorders (DSM-5) score for AUD = 0
Alcohol Use Disorders Identification Test (AUDIT) score ≤ 7
Is not a heavy alcohol consumer
DSM-5 score for AUD ≥ 3
AUDIT score ≥ 8
Is a heavy alcohol consumer

Exclusion

Current substance use disorder other than alcohol use disorder and/or frequent use of non-prescribed psychoactive substances.
Current serious psychiatric disorder, and/or any history of a psychotic disorder
Any health problem that would interfere with the study or could be aggravated by study procedures (e.g., history of migraines, claustrophobia).
Is currently taking or initiates a medication known to affect alcohol intake and/or craving.
History of traumatic brain injury resulting in hospitalization, loss of consciousness, and/or having ever been informed he/she has an epidural, subdural, or subarachnoid hemorrhage.
Does not meet safety criteria for TMS or MRI.
Females of childbearing potential who are pregnant (by urine HCG), planning to become pregnant, nursing, or who are not using a reliable form of birth control.
Is at an elevated risk of seizure (i.e. has a history of seizures, is currently prescribed medications known to lower seizure threshold and has had a change in their medication).
Clinical Intake Withdrawal Assessment (CIWA\>5) (to prevent delivering TMS to individuals in withdrawal).
Not able to read and understand questionnaires, assessments, and/or the informed consent.

What this trial measures

  • Number of Adverse Events Potentially Related to TMSThrough study completion 1 year

    The number of potential adverse events queried after each TMS session.