Cognitive Reappraisal Training for Borderline Personality Disorder

This study is exploring a new way to help people with Borderline Personality Disorder (BPD) manage their emotions. Researchers are testing "Cognitive Reappraisal by Distancing," a technique where you learn to change how you think about upsetting situations to reduce negative feelings. You would meet with a therapist twice a week for six weeks to practice this skill. Another group will also meet twice a week for six weeks to practice their usual ways of handling negative emotions. The study aims to see if this training can improve how your brain responds to negative images and ultimately help with BPD symptoms. You may be able to join if you are 18 to 55 years old, have BPD, and are medically healthy. The study is currently unclear on its recruitment status and plans to enroll 130 participants.

Study design
This interventional study plans to enroll 130 participants. It compares two behavioral interventions: Cognitive Reappraisal by Distancing and a Downregulate condition.
What's involved
Participants will meet with a therapist two times a week for six weeks. During these sessions, they will practice techniques related to managing negative emotions.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at baseline and after 6 weeks of treatment. Further follow-up is not specified.

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NCT06772831

Cognitive Reappraisal Training for Borderline Personality (BPD)

Recruiting
NAAges 18–55InterventionalTreatment
Icahn School of Medicine at Mount Sinai
~130 participants
Updated 2025-12-03 on ClinicalTrials.gov
What's tested:Cognitive Reappraisal by DistancingDownregulate condition

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Picture Induced Negative Emotion Signature (PINES) Network Activity
Measured over Baseline and 6 weeks of treatment
Borderline Personality Disorder
1 sites across 1 states
New York1
  • Harold W Koenigsberg, MD · PRINCIPAL_INVESTIGATOR · Icahn School of Medicine at Mount Sinai

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Eligibility criteria

Inclusion

Medically healthy men and women with Borderline Personality Disorder who are mentally competent and give informed voluntary written consent.
Participants will be between the ages of 18 and 55.
Participants with comorbid avoidant personality disorder will be included.
Participants who meet criteria for PTSD will be included as long as they are not actively experiencing symptoms.

Exclusion

Participants will not meet criteria for Schizotypal Personality Disorder.
Participants currently meeting criteria for Major Depressive Disorder will be excluded.
BPD participants will not meet DSM-5 criteria for present PTSD, bipolar I disorder, schizophrenia, schizoaffective disorder, substance use disorder within the past 6 months, organic mental syndromes, head trauma, schizotypal personality disorder, avoidant personality disorder, CNS neurological disease, or seizure disorder. Participants meeting criteria for a non-IV substance use disorder more than 6 months prior to enrollment will not be excluded. This study allows patients who are currently taking psychotropic medications or are in psychotherapy, so long as there has been no change in medication or psychotherapy over the preceding two months.
Participants currently meeting criteria for major depressive disorder.
Participants meeting criteria for substance use disorder within the last 6 months or of an IV-substance use disorder at any time.
Participants may not have a pacemaker, surgical clips, any metallic implants, or shrapnel fragments that would contraindicate MRI scanning.
Pregnant women.
  • Change in Picture Induced Negative Emotion Signature (PINES) Network ActivityBaseline and 6 weeks of treatment

    Change in Picture Induced Negative Emotion Signature (PINES) network activity. by measuring neural activation using fMRI.